A rat toxicological study of intra-arterial injection of Tirapazamine, a hypoxia-activating Cancer therapeutic agent, followed by hepatic artery ligation
Sign Up to like & getrecommendations! Published in 2021 at "Investigational New Drugs"
DOI: 10.1007/s10637-020-01057-3
Abstract: Background Tirapazamine’s (TPZ) tolerability after an intra-arterial (IA) injection remains unclear. We investigated TPZ’s safety and tolerability in rats by first injecting into the left hepatic artery and then performing a hepatic artery ligation, which… read more here.
Keywords: tpz; artery; artery ligation; hepatic artery ... See more keywords
Sorafenib-Encapsulated Liposomes to Activate Hypoxia-Sensitive Tirapazamine for Synergistic Chemotherapy of Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c18051
Abstract: Combination therapy with the synergistic effect is an effective way in cancer chemotherapy. Herein, an antiangiogenic sorafenib (SOR) and hypoxia-activated prodrug tirapazamine (TPZ)-coencapsulated liposome (LipTPZ/SOR) is prepared for chemotherapy of hepatocellular carcinoma (HCC). SOR is… read more here.
Keywords: effect; sor; tpz; chemotherapy ... See more keywords
A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr04021b
Abstract: The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials. Thus, the development of… read more here.
Keywords: system; hypoxia levels; tumor hypoxia; tpz ... See more keywords
Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Materials horizons"
DOI: 10.1039/d3mh00242j
Abstract: Phototherapy-induced hypoxia in the tumor microenvironment (TME) is responsible for diminished therapeutic efficacy. Designing an intelligent nanosystem capable of responding to hypoxia for TME-responsive drug delivery will, to some extent, improve the therapeutic efficacy and… read more here.
Keywords: semiconducting polymer; poly prodrug; tumor microenvironment; phototherapy ... See more keywords
A hypoxia-activated and tumor microenvironment-remodeling nanoplatform for augmenting sonodynamic-chemodynamic-chemotherapy of breast cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials science"
DOI: 10.1039/d5bm00060b
Abstract: The tumor microenvironment (TME) offers a promising approach to enhancing cancer therapy by altering the conditions that support tumor growth and immune evasion. However, tumors are highly heterogeneous, and the TME can vary greatly even… read more here.
Keywords: cancer; mno2; hypoxia activated; ce6 ... See more keywords
Introducing urea into tirapazamine derivatives to enhance anticancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "National Science Review"
DOI: 10.1093/nsr/nwae038
Abstract: ABSTRACT Tirapazamine (TPZ) has been approved for multiple clinical trials relying on its excellent anticancer potential. However, as a typical hypoxia-activated prodrug (HAP), TPZ did not exhibit survival advantages in Phase III clinical trials when… read more here.
Keywords: tirapazamine; ft11 tpzp; tpz; hypoxia ... See more keywords
Targeting triple‐negative breast cancer with an aptamer‐functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-021-00786-8
Abstract: Background Areas of hypoxia are often found in triple-negative breast cancer (TNBC), it is thus more difficult to treat than other types of breast cancer, and may require combination therapies. A new strategy that combined… read more here.
Keywords: tpz; treatment; breast cancer; ppix ... See more keywords
Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11060930
Abstract: Simple Summary Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules. In this study, a screening of 2000 novel molecules revealed a unique thienopyrazole derivative, Tpz-1, that elicited potent and selective… read more here.
Keywords: cell; pyrazole derivative; tpz; thieno pyrazole ... See more keywords
Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076863
Abstract: 3-Amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) and other heteroaromatic N-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities. Their action is attributed to the enzymatic single-electron reduction to free radicals that initiate the prooxidant processes. In order to clarify… read more here.
Keywords: tpz; tirapazamine; murine hepatoma; expression ... See more keywords
Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceuticals"
DOI: 10.3390/ph12010003
Abstract: Introduction: Benzotriazine-1,4-dioxides (BTDOs) such as tirapazamine (TPZ) and its derivatives act as radiosensitizers of hypoxic tissues. The benzotriazine-1-monoxide (BTMO) metabolite (SR 4317, TPZMO) of TPZ also has radiosensitizing properties, and via unknown mechanisms, is a… read more here.
Keywords: tpz; 131i eoe; eoe tpz; eoe ... See more keywords