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   Articles with "tpz" as a keyword



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A rat toxicological study of intra-arterial injection of Tirapazamine, a hypoxia-activating Cancer therapeutic agent, followed by hepatic artery ligation

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recommendations! Published in 2021 at "Investigational New Drugs"

DOI: 10.1007/s10637-020-01057-3

Abstract: Background Tirapazamine’s (TPZ) tolerability after an intra-arterial (IA) injection remains unclear. We investigated TPZ’s safety and tolerability in rats by first injecting into the left hepatic artery and then performing a hepatic artery ligation, which… read more here.

Keywords: tpz; artery; artery ligation; hepatic artery ... See more keywords
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A dual-response drug delivery system with X-ray and ROS to boost the anti-tumor efficiency of TPZ via enhancement of tumor hypoxia levels.

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recommendations! Published in 2022 at "Nanoscale"

DOI: 10.1039/d2nr04021b

Abstract: The selective anti-tumor activity and less toxic nature of hypoxia-activated prodrugs including tirapazamine (TPZ) are harbored by hypoxia levels in tumors, the inadequacy of which leads to failure in clinical trials. Thus, the development of… read more here.

Keywords: system; hypoxia levels; tumor hypoxia; tpz ... See more keywords
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Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy.

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recommendations! Published in 2023 at "Materials horizons"

DOI: 10.1039/d3mh00242j

Abstract: Phototherapy-induced hypoxia in the tumor microenvironment (TME) is responsible for diminished therapeutic efficacy. Designing an intelligent nanosystem capable of responding to hypoxia for TME-responsive drug delivery will, to some extent, improve the therapeutic efficacy and… read more here.

Keywords: semiconducting polymer; poly prodrug; tumor microenvironment; phototherapy ... See more keywords
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Targeting triple‐negative breast cancer with an aptamer‐functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies

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recommendations! Published in 2021 at "Journal of Nanobiotechnology"

DOI: 10.1186/s12951-021-00786-8

Abstract: Background Areas of hypoxia are often found in triple-negative breast cancer (TNBC), it is thus more difficult to treat than other types of breast cancer, and may require combination therapies. A new strategy that combined… read more here.

Keywords: tpz; treatment; breast cancer; ppix ... See more keywords
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Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro

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recommendations! Published in 2022 at "Biology"

DOI: 10.3390/biology11060930

Abstract: Simple Summary Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules. In this study, a screening of 2000 novel molecules revealed a unique thienopyrazole derivative, Tpz-1, that elicited potent and selective… read more here.

Keywords: cell; pyrazole derivative; tpz; thieno pyrazole ... See more keywords

Redox Proteomic Profile of Tirapazamine-Resistant Murine Hepatoma Cells

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24076863

Abstract: 3-Amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ) and other heteroaromatic N-oxides (ArN→O) exhibit tumoricidal, antibacterial, and antiprotozoal activities. Their action is attributed to the enzymatic single-electron reduction to free radicals that initiate the prooxidant processes. In order to clarify… read more here.

Keywords: tpz; tirapazamine; murine hepatoma; expression ... See more keywords

Development of [131I]I-EOE-TPZ and [131I]I-EOE-TPZMO: Novel Tirapazamine (TPZ)-Based Radioiodinated Pharmaceuticals for Application in Theranostic Management of Hypoxia

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recommendations! Published in 2019 at "Pharmaceuticals"

DOI: 10.3390/ph12010003

Abstract: Introduction: Benzotriazine-1,4-dioxides (BTDOs) such as tirapazamine (TPZ) and its derivatives act as radiosensitizers of hypoxic tissues. The benzotriazine-1-monoxide (BTMO) metabolite (SR 4317, TPZMO) of TPZ also has radiosensitizing properties, and via unknown mechanisms, is a… read more here.

Keywords: tpz; 131i eoe; eoe tpz; eoe ... See more keywords