Thioredoxin reductase 1 knockdown disrupts pigment synthesis in melanocytes
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.131
Abstract: Our labs have shown that levels of the antioxidant enzyme thioredoxin reductase 1 (TR1) is increased in human malignant melanomas relative to benign nevi (moles), and that TR1 knockdown affects mitochondrial metabolism in human melanomas.… read more here.
Keywords: thioredoxin reductase; reductase knockdown; tr1; knockdown disrupts ... See more keywords
Enhancement of Graft-Versus-Host Disease Control Efficacy by Adoptive Transfer of Type 1 Regulatory T Cells in Bone Marrow Transplant Model.
Sign Up to like & getrecommendations! Published in 2019 at "Stem cells and development"
DOI: 10.1089/scd.2018.0113
Abstract: Interleukin (IL)-10-producing type 1 regulatory T (Tr1) cells, which are Foxp3-memory T lymphocytes, play important roles in peripheral immune tolerance. We investigated whether Tr1 cells exert immunoregulatory effects in a mouse model of acute graft-versus-host… read more here.
Keywords: type regulatory; tr1 cells; tr1; versus host ... See more keywords
Combinations of anti-GITR antibody and CD28 superagonist induce permanent allograft acceptance by generating type 1 regulatory T cells
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo4413
Abstract: Type 1 regulatory T (Tr1) cells represent a subset of IL-10–producing CD4+Foxp3− T cells and play key roles in promoting transplant tolerance. However, no effective pharmacological approaches have been able to induce Tr1 cells in… read more here.
Keywords: tr1; permanent allograft; allograft acceptance; cd28 superagonist ... See more keywords
Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0179184
Abstract: Prostaglandin E2 (PGE2), a major lipid mediator abundant at inflammatory sites, acts as a proinflammatory agent in models of inflammatory/autoimmune diseases by promoting CD4 Th1/Th17 differentiation. Regulatory T cells, including the IL-10 producing Tr1 cells… read more here.
Keywords: production; pge2; tr1; maf ... See more keywords
Type 1 regulatory T cell-mediated tolerance in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1032575
Abstract: Type 1 regulatory T (Tr1) cells, in addition to other regulatory cells, contribute to immunological tolerance to prevent autoimmunity and excessive inflammation. Tr1 cells arise in the periphery upon antigen stimulation in the presence of… read more here.
Keywords: tr1; disease; mediated tolerance; tr1 cells ... See more keywords
Highly purified and functionally stable in vitro expanded allospecific Tr1 cells expressing immunosuppressive graft-homing receptors as new candidates for cell therapy in solid organ transplantation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1062456
Abstract: The development of new strategies based on the use of Tr1 cells has taken relevance to induce long-term tolerance, especially in the context of allogeneic stem cell transplantation. Although Tr1 cells are currently identified by… read more here.
Keywords: organ transplantation; tr1; highly purified; tr1 cells ... See more keywords
FoxP3− Tr1 Cell in Generalized Myasthenia Gravis and Its Relationship With the Anti-AChR Antibody and Immunomodulatory Cytokines
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2021.755356
Abstract: Introduction: The changes in the number and function of regulatory T cells (Tregs) are thought to play important roles in the pathogenesis of generalized myasthenia gravis (gMG). Previous studies have suggested the decrease of FoxP3+… read more here.
Keywords: anti achr; cd4; foxp3 treg; tr1 cell ... See more keywords