Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB
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DOI: 10.18632/oncotarget.24961
Abstract: Therapy-induced senescence is a major cellular response to chemotherapy in solid tumors. Senescent tumor cells acquire a secretory phenotype, or SASP, and produce pro-inflammatory factors, whose expression is largely under NF-κB transcriptional control. Secreted factors… read more here.
Keywords: secretory phenotype; senescent tumor; tumor cells; senescence ... See more keywords