Technological advances in ocular trabecular meshwork in vitro models for glaucoma research
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28182
Abstract: Glaucoma is the leading cause of irreversible blindness worldwide and is characterized by the progressive degeneration of the optic nerve. Intraocular pressure (IOP), which is considered to be the main risk factor for glaucoma development,… read more here.
Keywords: advances ocular; glaucoma research; trabecular meshwork; technological advances ... See more keywords
Optical sectioning and high resolution visualization of trabecular meshwork using Bessel beam assisted light sheet fluorescence microscopy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biophotonics"
DOI: 10.1002/jbio.201900048
Abstract: Glaucoma, one of the leading causes of blindness, is an eye disease caused by irregularities in the ocular aqueous outflow system causing an elevated intraocular pressure. High resolution imaging of the aqueous outflow system comprising… read more here.
Keywords: trabecular meshwork; high resolution; visualization trabecular; microscopy ... See more keywords
Acoustic radiation force optical coherence elastography: A preliminary study on biomechanical properties of trabecular meshwork
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202200317
Abstract: Evaluating biomechanical properties of trabecular meshwork (TM) is of great significance for understanding the mechanism of aqueous humor circulation and its relationship to some eye diseases such as glaucoma; however, there is almost no relevant… read more here.
Keywords: biomechanical properties; properties trabecular; trabecular meshwork; radiation force ... See more keywords
Glypican‐4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30953
Abstract: A common adverse response to the clinical use of glucocorticoids (GCs) is elevated intraocular pressure (IOP) which is a major risk factor for glaucoma. Elevated IOP arises due to impaired outflow of aqueous humor (AH)… read more here.
Keywords: wnt pcp; pcp signaling; pcp; trabecular meshwork ... See more keywords
Methods for Analyzing Endoplasmic Reticulum Stress in the Trabecular Meshwork of Glaucoma Models.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7407-8_12
Abstract: The pathological mechanisms underlying increased outflow resistance at the trabecular meshwork (TM) that is responsible for elevating intraocular pressure (IOP) have not been fully delineated. Recent studies have shown that progressive accumulation of misfolded proteins… read more here.
Keywords: trabecular meshwork; endoplasmic reticulum; reticulum stress; iop elevation ... See more keywords
Baicalin alleviates oxidative stress damage in trabecular meshwork cells in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1433-9
Abstract: Oxidative stress and inflammation play a key role in pathophysiology of glaucoma. Baicalin is known as an anti-oxidative and anti-inflammatory substance, possessing the potential to treat glaucoma. This study was designed to assess the anti-oxidative… read more here.
Keywords: trabecular meshwork; baicalin; htm cells; cells vitro ... See more keywords
Impact of pigment dispersion on trabecular meshwork cells
Sign Up to like & getrecommendations! Published in 2019 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-019-04300-7
Abstract: PurposeDysfunction of the trabecular meshwork (TM) in pigmentary glaucoma contributes to increased aqueous humor outflow resistance and intraocular pressure. In this study, we investigated the effect of pigment dispersion on trabecular meshwork cells.MethodsPorcine TM cells… read more here.
Keywords: meshwork cells; trabecular meshwork; dispersion trabecular; dispersion ... See more keywords
Rapamycin Removes Damaged Mitochondria and Protects Human Trabecular Meshwork (TM-1) Cells from Chronic Oxidative Stress
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1559-5
Abstract: Glaucoma is a chronic optic neuropathy that could lead to permanent vision loss. Primary open-angle glaucoma (POAG) is the most common type of glaucoma, with elevated intraocular pressure (IOP) as a major risk factor. IOP… read more here.
Keywords: trabecular meshwork; chronic oxidative; human trabecular; stress ... See more keywords
Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.178
Abstract: The trabecular meshwork (TM) is a tissue that originates from the neural crest via the periocular mesenchyme and plays a role in draining water and maintaining intraocular pressure (IOP). Damage to the TM is associated… read more here.
Keywords: neurotrophin receptor; trabecular meshwork; progenitor cells; p75 ... See more keywords
1α,25-dihydroxyvitamin D3 attenuates oxidative stress-induced damage in human trabecular meshwork cells by inhibiting TGFβ-SMAD3-VDR pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.027
Abstract: Evidence indicates that 1α, 25-dihydroxy vitamin D3 (1, 25-(OH)2D3) markedly reduces intraocular pressure (IOP) in nonhuman primates, while the biochemical mechanisms are unclear. To investigate the influence of oxidative stress on human trabecular meshwork cells… read more here.
Keywords: meshwork cells; trabecular meshwork; human trabecular; stress ... See more keywords
Nitric oxide: a drug target for glaucoma revisited.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.033
Abstract: A reduction in intraocular pressure (IOP) is the only recognized therapy for glaucoma. Hence, drugs exhibiting ocular hypotensive effects are important targets for antiglaucomatous drug development. IOP is determined by the equilibrium of aqueous humor… read more here.
Keywords: trabecular meshwork; oxide drug; drug; glaucoma ... See more keywords