Decarboxylative Amidation of Aryl/Heteroarylacetic Acids via Activated Esters through Traceless α-Functionalized Benzylic Radicals.
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DOI: 10.1021/acs.orglett.3c00927
Abstract: Unlike conventional amide synthesis, a decarboxylative amidation of aryl/heteroarylacetic acids by reaction with NHS and tert-butyl nitrite has been reported to afford both aliphatic and (hetero)aromatic amides in satisfactory yields. Mechanistic studies revealed a previously… read more here.
Keywords: functionalized benzylic; heteroarylacetic acids; decarboxylative amidation; amidation aryl ... See more keywords