A randomized, double‐blind, phase II study of oral histone deacetylase inhibitor resminostat plus S‐1 versus placebo plus S‐1 in biliary tract cancers previously treated with gemcitabine plus platinum‐based chemotherapy
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DOI: 10.1002/cam4.3813
Abstract: Effective second‐line chemotherapy options are limited in treating advanced biliary tract cancers (BTCs). Resminostat is an oral histone deacetylase inhibitor. Such inhibitors increase sensitivity to fluorouracil, the active form of S‐1. In the phase I… read more here.
Keywords: biliary tract; resminostat; study; histone deacetylase ... See more keywords
Statins associate with lower risk of biliary tract cancers: A systematic review and meta‐analysis
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DOI: 10.1002/cam4.4942
Abstract: Biliary tract cancers (BTCs), encompassing cholangiocarcinoma (CCA), gallbladder (GBC), and ampulla of Vater cancers (AVC), are common hepatobiliary cancer after hepatocellular carcinoma with a high mortality rate. As there is no effective chemopreventive agent to… read more here.
Keywords: associate lower; statins associate; tract cancers; biliary tract ... See more keywords
Is there a role for combined anti–PD‐1/CTLA‐4 checkpoint blockade in the management of advanced biliary tract cancers?
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DOI: 10.1002/cncr.34660
Abstract: Sahai et al. recently reported on a randomized phase 2 trial (BilT‐ 01) investigating chemoimmunotherapy (including the anti–PD‐1 antibody nivolumab) versus combined anti–PD‐1/CTLA‐4 checkpoint blockade (using nivolumab and ipilimumab) in patients with advanced biliary tract… read more here.
Keywords: combination; advanced biliary; tract cancers; treatment ... See more keywords
The prognostic effect of PNN in digestive tract cancers and its correlation with the tumor immune landscape in colon adenocarcinoma
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DOI: 10.1002/jcla.24327
Abstract: The present study investigated the expression, mutation, and methylation profile of PNN and its prognostic value in digestive tract cancers. The disparities in signaling pathways and the immune landscape in colon adenocarcinoma (COAD) based on… read more here.
Keywords: pnn; digestive tract; landscape colon; colon adenocarcinoma ... See more keywords
Targeting phosphoinositide‐3‐kinase pathway in biliary tract cancers: A remedial route?
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DOI: 10.1002/jcp.27673
Abstract: Biliary tract cancers (BTC) are aggressive tumours with a low survival rate. At the advent of the genomic era, various genetic mutations in cell signalling pathways have been incriminated in carcinogenesis. Genomic analysis studies have… read more here.
Keywords: biliary tract; phosphoinositide kinase; pathway btcs; tract cancers ... See more keywords
Clinical Characteristics of Pancreatic and Biliary Tract Cancers Associated with Lynch Syndrome.
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DOI: 10.1002/jhbp.1063
Abstract: BACKGROUND/PURPOSE Pancreatic and biliary tract cancers are one of the Lynch syndrome-associated malignancies. There are few reports describing the patients' background and clinical characteristics. METHODS We retrospectively reviewed the medical records of patients with Lynch… read more here.
Keywords: biliary tract; pancreatic biliary; tract cancers; clinical characteristics ... See more keywords
Current Progress in the Systemic Therapy for Biliary Tract Cancers.
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DOI: 10.1002/jhbp.939
Abstract: BACKGROUND Biliary tract cancers (BTCs) are heterogeneous cancers that include cancers of the bile duct and gallbladder. Although they are relatively uncommon, most patients with BTC are diagnosed at advanced-stage disease with high mortality rates.… read more here.
Keywords: biliary tract; current progress; systemic therapy; tract cancers ... See more keywords
Prognostic roles of leptin‐signaling proteins, PD‐L1, and tumor‐infiltrating lymphocytes in surgically‐resected biliary tract cancers
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DOI: 10.1002/jso.27140
Abstract: Biliary tract cancers are rare, with a poor patient prognosis. Leptin and programmed death‐ligand 1 (PD‐L1) influence CD8+ and forkhead box P3 (FOXP3)+ lymphocytes, and thus, cancer cell growth. We aimed to define the prognostic… read more here.
Keywords: roles leptin; prognostic roles; leptin signaling; tract cancers ... See more keywords
Pre-operative Sarcopenia Identifies Patients at Risk for Poor Survival After Resection of Biliary Tract Cancers
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DOI: 10.1007/s11605-018-3802-1
Abstract: IntroductionBiliary tract cancers (BTC) are aggressive malignancies that require complex surgical procedures. Patients with BTC can present with skeletal muscle depletion, yet the effects of muscle wasting (sarcopenia) on outcomes have not been well studied.… read more here.
Keywords: sarcopenia; pre operative; muscle; among patients ... See more keywords
Neurotrophic tropomyosin receptor kinase (NTRK) and nerve growth factor (NGF) are not expressed in Caucasian patients with biliary tract cancers: pooled data from three independent cohorts
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DOI: 10.1007/s12094-018-02030-6
Abstract: BackgroundNeuronal signaling has been implicated in the pathophysiology of multiple malignancies. In biliary tract cancers (BTCs), tumor cell expression of nerve growth factor (NGF) and its receptor neurotrophic tropomyosin receptor kinase (NTRK) has been reported… read more here.
Keywords: biliary tract; nerve growth; caucasian patients; tract cancers ... See more keywords
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
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DOI: 10.1016/j.jhep.2018.01.009
Abstract: BACKGROUND & AIMS Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large-scale genome… read more here.
Keywords: biliary tract; driver genes; origin; tract cancers ... See more keywords