TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
Sign Up to like & getrecommendations! Published in 2025 at "Febs Letters"
DOI: 10.1002/1873-3468.70110
Abstract: A signal transduction pathway has been defined in which ADP‐heptose activates the mammalian protein kinase ALPK1, which phosphorylates the adaptor protein TIFA, inducing its polymerisation and interaction with the E3 ubiquitin ligases TRAF2/c‐IAP1 and TRAF6.… read more here.
Keywords: degradation; tifa via; binds tifa; via novel ... See more keywords
Up-regulation of TRAF2 inhibits chondrocytes apoptosis in lumbar facet joint osteoarthritis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.096
Abstract: Tumor necrosis factor receptor-associated factor 2 (TRAF2) has been demonstrated that it plays a significant role in cell death receptor signal transduction. The purpose of this study was to investigate the expression of TRAF2 and… read more here.
Keywords: regulation traf2; traf2; traf2 inhibits; chondrocytes apoptosis ... See more keywords
TSG‐6 inhibits hypertrophic scar fibroblast proliferation by regulating IRE1α/TRAF2/NF‐κB signalling
Sign Up to like & getrecommendations! Published in 2022 at "International Wound Journal"
DOI: 10.1111/iwj.13950
Abstract: TNF‐stimulated gene (TSG‐6) was reported to suppress hypertrophic scar (HS) formation in a rabbit ear model, and the overexpression of TSG‐6 in human HS fibroblasts (HSFs) was found to induce their apoptotic death. The molecular… read more here.
Keywords: traf2 signalling; hypertrophic scar; tsg; proliferation ... See more keywords
TRAF2 Knockdown in Nasopharyngeal Carcinoma Induced Cell Cycle Arrest and Enhanced the Sensitivity to Radiotherapy
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/1641340
Abstract: TRAF2 is a crucial adaptor protein involved in various signaling pathways. However, its biological functions in nasopharyngeal carcinoma (NPC) remain largely unknown. In the present study, we found that TRAF2 was overexpressed in nasopharyngeal carcinoma… read more here.
Keywords: traf2 knockdown; nasopharyngeal carcinoma; traf2; cell cycle ... See more keywords
Abstract 5088: Evaluating TNF-receptor associated factor 2 (TRAF2) as a targetable driver of immune resistance in LKB1 deficient non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-5088
Abstract: STK11 is a serine-threonine kinase and tumor suppressor lost in about 25% of NSCLC. It potently regulates a network of downstream effector kinases in the AMPK family, thereby exerting major effects on cell signaling, metabolic… read more here.
Keywords: cancer; resistance; traf2; ciap1 ... See more keywords
MicroRNA-647 promotes the therapeutic effectiveness of argon–helium cryoablation and inhibits cell proliferation through targeting TRAF2 via the NF-κB signaling pathway in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s159337
Abstract: Background MicroRNA-647 (miR-647) has been reported to repress cell tumorigenic phenotype, while the function of miR-647 in non-small cell lung cancer was obscure. Methods The effect of miR-647 and TRAF2 on A549 and H1299 cells… read more here.
Keywords: traf2; mir 647; non small; cell ... See more keywords
The role of TRAF2 in pan-cancer revealed by integrating informatics and experimental validation
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1563435
Abstract: Background Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an E3 ubiquitin ligase and scaffolding protein that contribute to the progression of various malignant tumors. However, the role of TRAF2 expression in epigenetic, cancer… read more here.
Keywords: database; cancer; role traf2; traf2 ... See more keywords
Evaluating the Topological Features of Monomeric and Trimeric TRAF2-C: A Multi-Disciplinary Approach
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DOI: 10.3390/biom15111626
Abstract: This study investigates the structural dynamics of the TRAF2 C-terminal domain (TRAF2-C), a key adaptor protein in TNF receptor signaling. TRAF2 usually forms trimers, but its ability to dissociate into monomers is critical for regulating… read more here.
Keywords: evaluating topological; monomeric trimeric; features monomeric; traf2 ... See more keywords
One for All, All for One: The Peculiar Dynamics of TNF-Receptor-Associated Factor (TRAF2) Subunits
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DOI: 10.3390/sym14040720
Abstract: TNF Receptor-Associated Factor 2 (TRAF2) is a homo-trimer belonging to the TNF-receptor-associated factor family (TRAFs). The TRAF2 oligomeric state is crucial for receptor binding, the interaction with other proteins (involved in the TNFR signaling), and… read more here.
Keywords: tnf receptor; traf2; receptor; receptor associated ... See more keywords
High glucose and bupivacaine-induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK-ATF4-CHOP and IRE1-TRAF2 signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10524
Abstract: Bupivacaine has previously been reported to induce neurotoxicity, which is further enhanced by high glucose levels. In the present study, the underlying molecular mechanisms via which bupivacaine induces cytotoxicity under high glucose conditions were investigated… read more here.
Keywords: apoptosis; traf2; glucose bupivacaine; high glucose ... See more keywords