TRAF3 delays cyst formation induced by NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2017 at "IUBMB Life"
DOI: 10.1002/iub.1601
Abstract: This study aims to investigate the effects of TNF receptors associated factor 3 (TRAF3) on the signaling pathway and expression of downstream products of nuclear factor kappa B (NF‐κB) in the epithelial cells of renal… read more here.
Keywords: pkd epithelial; traf3; epithelial cells; cyst formation ... See more keywords
FBXO11 amplifies type I interferon signaling to exert antiviral effects by facilitating the assemble of TRAF3–TBK1–IRF3 complex
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28655
Abstract: As the key component of host innate antiviral immunity, type I interferons (IFN‐Is) exert multiple antiviral effects by inducing hundreds of IFN‐stimulated genes. However, the precise mechanism involved in host sensing of IFN‐I signaling priming… read more here.
Keywords: tbk1; ifn signaling; traf3; tbk1 irf3 ... See more keywords
The prevalence and characterisation of TRAF3 and POT1 mutations in canine B-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary journal"
DOI: 10.1016/j.tvjl.2020.105575
Abstract: The genetic and mutational basis of canine lymphoma remains poorly understood. Several genes, including TRAF3 and POT1, are mutated in canine B-cell lymphoma (cBCL), and are likely involved in the pathogenesis of this disease. The… read more here.
Keywords: cell lymphoma; pot1 mutations; traf3; traf3 pot1 ... See more keywords
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01977-z
Abstract: The pathogenesis of doxorubicin-induced cardiomyopathy remains unclear. This study was carried out to test our hypothesis that ADAM17 aggravates cardiomyocyte apoptosis induced by doxorubicin and inhibition of ADAM17 may ameliorate doxorubicin-induced cardiomyopathy. C57BL/6J mice were… read more here.
Keywords: mice; adam17; traf3; doxorubicin induced ... See more keywords
Hepatoprotective effects of sevoflurane against hepatic ischemia-reperfusion injury by regulating microRNA-124-3p-mediated TRAF3/CREB axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00784-7
Abstract: The purpose of the present study is to define the role of sevoflurane (SEV) in hepatic ischemia-reperfusion (I/R) injury as well as its underlying mechanism. Initially, hepatic I/R animal models and I/R hepatocyte models were… read more here.
Keywords: injury; mir 124; creb axis; traf3 ... See more keywords
TRAF3 negatively regulates platelet activation and thrombosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17189-1
Abstract: CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L.… read more here.
Keywords: cd40l; platelet activation; activation; traf3 ... See more keywords
Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac379
Abstract: Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor… read more here.
Keywords: traf3; infection; traf3 variant; negative traf3 ... See more keywords
USP33 PROMOTES CERULEIN-INDUCED APOPTOTIC, OXIDATIVE, AND INFLAMMATORY INJURIES IN ACUTE PANCREATITIS BY DEUBIQUITINATING TRAF3
Sign Up to like & getrecommendations! Published in 2024 at "Shock"
DOI: 10.1097/shk.0000000000002514
Abstract: ABSTRACT Background: Tumor necrosis factor receptor associated factor 3 (TRAF3) and deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) have been identified to play important roles in inflammatory diseases, including acute pancreatitis (AP). Here, we aimed to… read more here.
Keywords: induced apoptotic; oxidative stress; hpde6 cells; cerulein induced ... See more keywords
Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Microbiology"
DOI: 10.1111/cmi.12769
Abstract: The success of pathogens depends on their ability to circumvent immune defences. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity… read more here.
Keywords: subversion innate; immune responses; responses francisella; francisella ... See more keywords
TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abn5507
Abstract: Type I interferons (IFNs) are among the most powerful tools that host cells deploy against intracellular pathogens. Their effectiveness is due both to the rapid, directly antiviral effects of IFN-stimulated gene products and to the… read more here.
Keywords: type; phosphatase ptpn22; traf3; receptor ... See more keywords
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008002
Abstract: The galectin 3 binding protein (LGALS3BP, also known as 90K) is a ubiquitous multifunctional secreted glycoprotein originally identified in cancer progression. It remains unclear how 90K functions in innate immunity during viral infections. In this… read more here.
Keywords: traf3 complex; traf6 traf3; inducible lgals3bp; lgals3bp 90k ... See more keywords