Overexpression of TRAF4 promotes lung cancer growth and EGFR‐dependent phosphorylation of ERK5
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13458
Abstract: Tumor necrosis factor receptor‐associated factor 4 (TRAF4) is overexpressed in a variety of carcinomas of different origins, but its role in tumorigenesis remains incompletely understood. Previous studies suggest that TRAF4 promotes epidermal growth factor receptor… read more here.
Keywords: lung cancer; kinase; phosphorylation erk5; traf4 promotes ... See more keywords
Down-regulation of TRAF4 targeting RSK4 inhibits proliferation, invasion and metastasis in breast cancer xenografts.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.164
Abstract: Ribosomal S6 protein kinase 4 (RSK4) was known as a novel tumor suppressor gene, and the tumor necrosis factor receptor-associated factor 4 (TRAF4) was linked to carcinogenesis. The purpose of this study is to further… read more here.
Keywords: metastasis; invasion metastasis; proliferation invasion; traf4 ... See more keywords
TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218229120
Abstract: Castration-resistant prostate cancer (CRPC) poses a major clinical challenge with the androgen receptor (AR) remaining to be a critical oncogenic player. Several lines of evidence indicate that AR induces a distinct transcriptional program after androgen… read more here.
Keywords: prostate cancer; androgen; receptor; castration ... See more keywords
Novel Findings in Teleost TRAF4, a Protein Acts as an Enhancer in TRIF and TRAF6 Mediated Antiviral and Inflammatory Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.944528
Abstract: Tumor necrosis factor receptor-associated factors (TRAFs) are important adaptor molecules that play important roles in host immune regulation and inflammatory responses. Compared to other members of TRAFs, the function of TRAF4 in vertebrate immunity remains… read more here.
Keywords: trif traf6; inflammatory; traf4; finger ... See more keywords
TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.855139
Abstract: Tumor necrosis factor receptor associated factor 4 (TRAF4) is a RING domain E3 ubiquitin ligase that mediates the ubiquitination of various proteins and plays an important role in driving tumor progression. By studying the relationship… read more here.
Keywords: eg5; breast cancer; ubiquitination; traf4 ... See more keywords
Role of the overexpression of TRAF4 in predicting the prognosis of intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of oncology"
DOI: 10.3892/ijo.2018.4383
Abstract: The incidence of intrahepatic cholangiocarcinoma (ICC) is progressively increasing worldwide, and its prognosis remains poor. Accumulating evidence has demonstrated that tumor necrosis factor receptor-associated factor 4 (TRAF4), an adaptor protein, is involved in the carcinogenesis and progression… read more here.
Keywords: prognosis; overexpression traf4; intrahepatic cholangiocarcinoma; traf4 predicting ... See more keywords