An Antioxidant Sesquiterpene Inhibits Osteoclastogenesis Via Blocking IPMK/TRAF6 and Counteracts OVX‐Induced Osteoporosis in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4328
Abstract: Excessive bone resorption induced by increased osteoclast activity in postmenopausal women often causes osteoporosis. Although the pharmacological treatment of osteoporosis has been extensively developed, a safer and more effective treatment is still needed. Here, we… read more here.
Keywords: traf6; treatment; antioxidant sesquiterpene; ipmk traf6 ... See more keywords
MiR-146a-5p promotes IL-1β-induced chondrocyte apoptosis through the TRAF6-mediated NF-kB pathway
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DOI: 10.1007/s00011-020-01346-w
Abstract: Objective This study aimed to explore the role of the miR-146a-5p/TRAF6/NF-KB axis in chondrocyte apoptosis. Methods Transcriptome sequencing for microRNA expression in control and osteoarthritic cartilage was performed. Bioinformatic analysis was performed to identify the… read more here.
Keywords: traf6 mediated; chondrocyte apoptosis; traf6; mir 146a ... See more keywords
miR-146a Inhibits dengue-virus-induced autophagy by targeting TRAF6
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Virology"
DOI: 10.1007/s00705-017-3516-9
Abstract: During dengue virus (DENV) infection, the virus manipulates different cellular pathways to assure productive replication, including autophagy. However, it remains unclear how this autophagic process is regulated. Here, we have demonstrated a novel role for… read more here.
Keywords: dengue virus; induced autophagy; traf6; mir 146a ... See more keywords
The lncRNA ROR/miR-124-3p/TRAF6 axis regulated the ischaemia reperfusion injury-induced inflammatory response in human cardiac myocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09812-9
Abstract: Myocardial ischaemia reperfusion injury (MIRI) is considered the primary cause of death in patients with cardiovascular diseases. Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been found to be involved in the pathogenesis of… read more here.
Keywords: lncrna ror; traf6; ror; cell apoptosis ... See more keywords
Long non-coding RNA HCG18 promotes M1 macrophage polarization through regulating the miR-146a/TRAF6 axis, facilitating the progression of diabetic peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03923-3
Abstract: Diabetic peripheral neuropathy (DPN) is one of the most important complications in diabetes mellitus (DM), which has been reported to be modulated by long non-coding RNAs (lncRNAs). The purpose of the current study is to… read more here.
Keywords: lncrna hcg18; traf6; mir 146a; macrophage polarization ... See more keywords
MicroNAR-194-5p hinders the activation of NLRP3 inflammasomes and alleviates neuroinflammation during intracerebral hemorrhage by blocking the interaction between TRAF6 and NLRP3
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2020.147228
Abstract: The possible role of miR-194-5p in brain and neurodegenerative diseases has been reported, but its role in intracerebral hemorrhage (ICH) has not been studied. This study estimated the mechanism of miR-194-5p in ICH. ICH rat… read more here.
Keywords: traf6 nlrp3; traf6; nlrp3 inflammasomes; activation nlrp3 ... See more keywords
TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis
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DOI: 10.1016/j.celrep.2018.01.013
Abstract: SUMMARY Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe… read more here.
Keywords: homeostasis; traf6; hematopoietic stem; activation ... See more keywords
Tumor necrosis factor receptor‐associated factor 6 (TRAF6) participates in anti‐lipopolysaccharide factors (ALFs) gene expression in mud crab
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.08.015
Abstract: ABSTRACT Tumor necrosis factor receptor‐associated factor 6 (TRAF6) is a key cytoplasm signal adaptor that mediates signals activated by tumor necrosis factor receptor (TNFR) superfamily and the Interleukin‐1 receptor/Toll‐like receptor (IL‐1/TLR) superfamily. The full‐length 2492… read more here.
Keywords: receptor; factor; traf6; gene expression ... See more keywords
Involvement of TRAF6 in Regulating Immune Defense and Ovarian Development in Musca domestica.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.10.259
Abstract: The tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is a key cytoplasm signaling adaptor that mediates signals activated by TNFR superfamily and the interleukin-1/Toll-like receptor (IL-1/TLR) superfamily. In the present research, a housefly Musca… read more here.
Keywords: musca domestica; ovarian development; traf6;
The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01665-3
Abstract: Ubiquitin chains linked through lysine63 (K63) play a critical role in inflammatory signalling. Following ligand engagement of immune receptors, the RING E3 ligase TRAF6 builds K63-linked chains together with the heterodimeric E2 enzyme Ubc13-Uev1A. Dimerisation… read more here.
Keywords: traf6; zinc finger; activity; ubiquitin chains ... See more keywords
Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity
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DOI: 10.1038/s41598-020-61972-6
Abstract: TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a… read more here.
Keywords: traf6; tifa dependent; analysis; tifa traf6 ... See more keywords