Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC
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DOI: 10.1101/2022.07.19.500647
Abstract: ADP-heptose activates the protein kinase ALPK1 triggering TIFA phosphorylation at Thr9, the recruitment of TRAF6 and the subsequent production of inflammatory mediators. Here, we demonstrate that ADP-heptose also stimulates the formation of Lys63- and Met1-linked… read more here.
Keywords: traf2 iap1; adp heptose; traf6 traf2; ligases traf6 ... See more keywords