Quantitative Analysis of Membrane Receptor Trafficking Manipulated by Optogenetic Tools.
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DOI: 10.1007/978-1-0716-1258-3_2
Abstract: Membrane receptors play a crucial role in transmitting external signals inside cells. Signal molecule-bound receptors activate multiple downstream pathways, the dynamics of which are modulated by intracellular trafficking. A significant contribution of β-arrestin to intracellular… read more here.
Keywords: trafficking; quantitative analysis; receptor trafficking; membrane receptor ... See more keywords
Rapid and facile quantitation of polyplex endocytic trafficking
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2016.12.035
Abstract: ABSTRACT Design of safe and effective synthetic nucleic acid delivery vectors such as polycation/DNA or polycation/siRNA complexes (polyplexes) will be facilitated by quantitative understanding of the mechanisms by which such materials escort cargo from the… read more here.
Keywords: subcellular fractionation; endocytic trafficking; trafficking; microscopy ... See more keywords
Dual function of PI(4,5)P2 in insulin-regulated exocytic trafficking of GLUT4 in adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.06.019
Abstract: Phosphoinositides are important signaling molecules involved in the regulation of vesicular trafficking. It has been implicated that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is involved in insulin-regulated GLUT4 translocation in adipocytes. However, it remains unclear where and how… read more here.
Keywords: insulin; vesicle; trafficking; vesicle docking ... See more keywords
Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes
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DOI: 10.1016/j.molmet.2017.11.011
Abstract: Objective Intracellular vesicle trafficking maintains cellular structures and functions. The assembly of cargo-laden vesicles at the trans-Golgi network is initiated by the ARF family of small GTPases. Here, we demonstrate the role of the trans-Golgi… read more here.
Keywords: insulin; trafficking; trans golgi; insulin receptor ... See more keywords
Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
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DOI: 10.1091/mbc.e18-12-0811
Abstract: Megalin (gp330, LRP-2) is a protein structurally related to the low-density lipoprotein receptor family that displays a large luminal domain with multiligand binding properties. Megalin localizes to the apical surface of multiple epithelia, where it… read more here.
Keywords: clathrin clathrin; megalin biosynthetic; trafficking; megalin ... See more keywords
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
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DOI: 10.1172/jci89857
Abstract: Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by multiple viruses could offer broad-spectrum solutions. We previously reported that AAK1 and GAK,… read more here.
Keywords: aak1 gak; trafficking; kinase; sunitinib erlotinib ... See more keywords
The Meckel syndrome- associated protein MKS1 functionally interacts with components of the BBSome and IFT complexes to mediate ciliary trafficking and hedgehog signaling
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DOI: 10.1371/journal.pone.0173399
Abstract: The importance of primary cilia in human health is underscored by the link between ciliary dysfunction and a group of primarily recessive genetic disorders with overlapping clinical features, now known as ciliopathies. Many of the… read more here.
Keywords: protein; trafficking; meckel syndrome; protein mks1 ... See more keywords
Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells
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DOI: 10.1371/journal.ppat.1010434
Abstract: Enterococcus faecalis is a frequent opportunistic pathogen of wounds, whose infections are associated with biofilm formation, persistence, and recalcitrance toward treatment. We have previously shown that E. faecalis wound infection persists for at least 7… read more here.
Keywords: faecalis; faecalis alters; trafficking; infection ... See more keywords
Variation in Membrane Trafficking Linked to SNARE AtSYP51 Interaction With Aquaporin NIP1;1
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DOI: 10.3389/fpls.2018.01949
Abstract: SYP51 and 52 are the two members of the SYP5 Qc-SNARE gene family in Arabidopsis thaliana. These two proteins, besides their high level of sequence identity (85%), have shown to have differential functional specificity and… read more here.
Keywords: trafficking; aquaporin; syp51; interaction ... See more keywords
Allelic RNA Motifs in Regulating Systemic Trafficking of Potato Spindle Tuber Viroid
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DOI: 10.3390/v10040160
Abstract: Intercellular RNA trafficking has been shown as a widely-existing phenomenon that has significant functions in many aspects of biology. Viroids, circular noncoding RNAs that cause plant diseases, have been a model to dissect the role… read more here.
Keywords: potato spindle; trafficking; rna; motifs regulating ... See more keywords