A genetic screen in combination with biochemical analysis in Saccharomyces cerevisiae indicates that phenazine-1-carboxylic acid is harmful to vesicular trafficking and autophagy
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DOI: 10.1038/s41598-017-01452-6
Abstract: The environmentally friendly antibiotic phenazine-1-carboxylic acid (PCA) protects plants, mammals and humans effectively against various fungal pathogens. However, the mechanism by which PCA inhibits or kills fungal pathogens is not fully understood. We analyzed the… read more here.
Keywords: vesicular trafficking; saccharomyces cerevisiae; phenazine carboxylic; carboxylic acid ... See more keywords
This Is the End: Regulation of Rab7 Nucleotide Binding in Endolysosomal Trafficking and Autophagy
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DOI: 10.3389/fcell.2018.00129
Abstract: Rab7 – or in yeast, Ypt7p – governs membrane trafficking in the late endocytic and autophagic pathways. Rab7 also regulates mitochondrion-lysosome contacts, the sites of mitochondrial fission. Like all Rab GTPases, Rab7 cycles between an… read more here.
Keywords: rab7 nucleotide; nucleotide binding; endolysosomal trafficking; trafficking autophagy ... See more keywords