N-glycosylation of α1D-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64102-4
Abstract: G protein-coupled receptor (GPCR) biogenesis, trafficking, and function are regulated by post-translational modifications, including N-glycosylation of asparagine residues. α1D-adrenergic receptors (α1D-ARs) – key regulators of central and autonomic nervous system function – contain two putative… read more here.
Keywords: trafficking function; glycosylation; receptor; domain ... See more keywords
Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20160296
Abstract: By interacting directly with partner proteins and with one another, tetraspanins organize a network of interactions referred to as the tetraspanin web. ADAM10 (A Disintegrin And Metalloprotease 10), an essential membrane-anchored metalloprotease that cleaves off… read more here.
Keywords: adam10; trafficking function; metalloprotease; function metalloprotease ... See more keywords
Conserved but not critical: Trafficking and function of NaV1.7 are independent of highly conserved polybasic motifs
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1161028
Abstract: Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (NaV) channels are an attractive target for pain therapy because they initiate and propagate action potentials in primary afferents that detect… read more here.
Keywords: rab6a; polybasic motifs; trafficking function; critical trafficking ... See more keywords
Trafficking and Function of the Voltage-Gated Sodium Channel β2 Subunit
Sign Up to like & getrecommendations! Published in 2019 at "Biomolecules"
DOI: 10.3390/biom9100604
Abstract: The voltage-gated sodium channel is vital for cardiomyocyte function, and consists of a protein complex containing a pore-forming α subunit and two associated β subunits. A fundamental, yet unsolved, question is to define the precise… read more here.
Keywords: trafficking function; sodium channel; function; gated sodium ... See more keywords