Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosis
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DOI: 10.26508/lsa.201900439
Abstract: This study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis. Shiga toxin 1 (STx1) and 2 (STx2),… read more here.
Keywords: trafficking shiga; early endosome; toxin; shiga toxin ... See more keywords