Therapeutic targeting of TRAIL death receptors
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DOI: 10.1042/bst20220098
Abstract: The discovery of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) along with its potent and selective antitumor effects initiated a decades-long search for therapeutic strategies to target the TRAIL pathway. First-generation approaches were focused on the… read more here.
Keywords: generation approaches; trail; targeting trail; trail pathway ... See more keywords
Abstract 4457: Post exposure suppression of radiation pneumonitis by TRAIL pathway agonists TLY012 and ONC201
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4457
Abstract: Thoracic therapeutic ionizing radiation is limited by toxicities such as pneumonitis and fibrosis of the lungs. Such limitation restricts therapeutic doses and adversely affects patient quality of life while undergoing and following treatment. ONC201/TIC10 is… read more here.
Keywords: trail; radiation pneumonitis; tly012 onc201; trail pathway ... See more keywords