Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2020.05.012
Abstract: Highlights • We evaluated the effect of the second-generation TRAIL receptor agonist APG-880 on radiation-induced cytotoxicity.• The combined effect was studied in short-term and long-term cytotoxicity assays in established CRC cell lines, and tumor organoids… read more here.
Keywords: receptor agonist; trail receptor; effect; second generation ... See more keywords
Dipeptidyl peptidase-4 inhibitor protects against non-alcoholic steatohepatitis in mice by targeting TRAIL receptor-mediated lipoapoptosis via modulating hepatic dipeptidyl peptidase-4 expression
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-75288-y
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP4i) are antidiabetic medications that prevent cleavage of incretin hormones by dipeptidyl peptidase-4 (DPP4). DPP4 is ubiquitously expressed, and its hepatic DPP4 expression is upregulated under non-alcoholic steatohepatitis (NASH) conditions. We investigated… read more here.
Keywords: trail receptor; peptidase; expression; mice ... See more keywords
A New Efficient Method for Production of Recombinant Antitumor Cytokine TRAIL and Its Receptor-Selective Variant DR5-B
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297919060051
Abstract: The cytokine TRAIL induces apoptosis in tumor cells of various origin without affecting normal cells. Clinical trials of TRAIL-receptor (DR4 and DR5) agonists (recombinant TRAIL or death receptors antibodies) have largely failed because most human… read more here.
Keywords: efficient method; cytokine trail; dr5; trail ... See more keywords
Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01530
Abstract: Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) signaling is far more complex than initially anticipated and can lead to either anti- or protumorigenic effects, hampering the successful clinical use of therapeutic TRAIL receptor agonists.… read more here.
Keywords: trail signaling; trail; trail receptor; tumor microenvironment ... See more keywords