PGI2 restricts trained ILC2 responses in allergic inflammation.
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DOI: 10.1093/jimmun/vkaf088
Abstract: Pulmonary type 2 innate lymphoid cells (ILC2s) exhibit immune memory, termed "trained immunity," which enhances their activation following exposure to an independent protease-containing allergen. The role of prostaglandin I2 (PGI2), a cyclooxygenase (COX) pathway metabolite,… read more here.
Keywords: mice; ilc2 responses; trained ilc2; responses allergic ... See more keywords