Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202413562
Abstract: Minimally invasive irreversible electroporation ablation shows promise for pancreatic cancer (PCa), but the high recurrence and metastasis rates pose a therapeutic challenge for loco‐regional ablation treatment. Immunotherapy holds promise for preventing tumor recurrence, however, its… read more here.
Keywords: myeloid cells; pca; splenic myeloid; trained immunity ... See more keywords
BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis
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DOI: 10.1002/advs.202504101
Abstract: Trained immunity, an innate immune memory, has emerged as a promising strategy to enhance host defense against sepsis, a leading cause of mortality in critical care. While Bacillus Calmette–Guérin (BCG) is the most widely used… read more here.
Keywords: outer membrane; immunity; membrane vesicles; trained immunity ... See more keywords
Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance.
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DOI: 10.1002/advs.202504245
Abstract: Trained immunity induced by β‐glucan insult drives the functional reprogramming of macrophages to the hyperinflammatory status, contributing to developing or maintaining inflammatory diseases. Inflammatory arthritis is characterized by an idiopathically hyperinflammatory response, a phenotype similar… read more here.
Keywords: trained immunity; inflammatory arthritis; arthritis progression; immunity ... See more keywords
Can BCG vaccine protect against COVID‐19 via trained immunity and tolerogenesis?
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000200
Abstract: As the number of infections and mortalities from the SARS‐CoV‐2 pandemic continues to rise, the development of an effective therapy against COVID‐19 becomes ever more urgent. A few reports showing a positive correlation between BCG… read more here.
Keywords: covid; trained immunity; bcg; immunity tolerogenesis ... See more keywords
Trained immunity from the perspective of Plasmodium Infection.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250268
Abstract: The immune system of vertebrates includes innate immunity and adaptive immunity, and the network between them enables the host to fight against invasions of various pathogens. Recently, studies discovered that immune memory is one of… read more here.
Keywords: plasmodium; trained immunity; immunity; innate immune ... See more keywords
The impact of trained immunity in respiratory viral infections
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DOI: 10.1002/rmv.2510
Abstract: Epidemic peaks of respiratory viruses that co‐circulate during the winter‐spring seasons can be synchronous or asynchronous. The occurrence of temporal patterns in epidemics caused by some respiratory viruses suggests that they could negatively interact with… read more here.
Keywords: impact trained; respiratory viruses; respiratory; trained immunity ... See more keywords
2D Transition Metal Dichalcogenides Trigger Trained Immunity in Human Macrophages through Epigenetic and Metabolic Pathways.
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DOI: 10.1002/smll.202107816
Abstract: Trained immunity is a recently described phenomenon whereby cells of the innate immune system undergo long-term epigenetic and/or metabolic reprogramming following a short-term interaction with microbes or microbial products. Here, it is shown that 2D… read more here.
Keywords: metal dichalcogenides; transition metal; immunity; trained immunity ... See more keywords
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.059
Abstract: Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose, we developed a… read more here.
Keywords: immunity; checkpoint inhibition; potentiates checkpoint; trained immunity ... See more keywords
BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils
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DOI: 10.1016/j.celrep.2020.108387
Abstract: Summary The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies… read more here.
Keywords: bcg vaccination; induces long; human neutrophils; vaccination ... See more keywords
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
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DOI: 10.1016/j.celrep.2021.108955
Abstract: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post-translational… read more here.
Keywords: anti inflammatory; cytokine interleukin; inflammatory cytokine; trained immunity ... See more keywords
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections
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DOI: 10.1016/j.celrep.2021.110184
Abstract: Summary MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism of action remains poorly understood. Here, we find that intranasal… read more here.
Keywords: protection; trained immunity; respiratory infections; vaccine ... See more keywords