Can BCG vaccine protect against COVID‐19 via trained immunity and tolerogenesis?
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000200
Abstract: As the number of infections and mortalities from the SARS‐CoV‐2 pandemic continues to rise, the development of an effective therapy against COVID‐19 becomes ever more urgent. A few reports showing a positive correlation between BCG… read more here.
Keywords: covid; trained immunity; bcg; immunity tolerogenesis ... See more keywords
Trained immunity from the perspective of Plasmodium Infection.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250268
Abstract: The immune system of vertebrates includes innate immunity and adaptive immunity, and the network between them enables the host to fight against invasions of various pathogens. Recently, studies discovered that immune memory is one of… read more here.
Keywords: plasmodium; trained immunity; immunity; innate immune ... See more keywords
2D Transition Metal Dichalcogenides Trigger Trained Immunity in Human Macrophages through Epigenetic and Metabolic Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202107816
Abstract: Trained immunity is a recently described phenomenon whereby cells of the innate immune system undergo long-term epigenetic and/or metabolic reprogramming following a short-term interaction with microbes or microbial products. Here, it is shown that 2D… read more here.
Keywords: metal dichalcogenides; transition metal; immunity; trained immunity ... See more keywords
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.059
Abstract: Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose, we developed a… read more here.
Keywords: immunity; checkpoint inhibition; potentiates checkpoint; trained immunity ... See more keywords
BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.108387
Abstract: Summary The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immunity. Recent studies… read more here.
Keywords: bcg vaccination; induces long; human neutrophils; vaccination ... See more keywords
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108955
Abstract: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post-translational… read more here.
Keywords: anti inflammatory; cytokine interleukin; inflammatory cytokine; trained immunity ... See more keywords
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections
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DOI: 10.1016/j.celrep.2021.110184
Abstract: Summary MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. However, its mechanism of action remains poorly understood. Here, we find that intranasal… read more here.
Keywords: protection; trained immunity; respiratory infections; vaccine ... See more keywords
Dectin-1b activation by arabinoxylans induces trained immunity in human monocyte-derived macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.04.071
Abstract: Arabinoxylans of various structures and sources have shown to possess the ability to induce a range of immune responses in different cell types in vitro and in vivo. Although the underlying mechanisms remain to be… read more here.
Keywords: activation; activation arabinoxylans; immunity; arabinoxylans induces ... See more keywords
NOD2-dependent BCG-induced trained immunity: A way to regulate innate responses to SARS-CoV2?
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.09.1429
Abstract: Bacillus Calmette-Guérin (BCG) vaccination was shown to reduce the susceptibility of respiratory viral infections by induction of potent innate immune memory termed trained immunity. Epidemiological studies on Covid-19 disease suggested that countries maintaining long-standing universal… read more here.
Keywords: innate; bcg; sars cov2; bcg induced ... See more keywords
Microglial Priming as Trained Immunity in the Brain
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DOI: 10.1016/j.neuroscience.2017.12.039
Abstract: In this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that… read more here.
Keywords: microglial priming; priming; priming trained; brain ... See more keywords
BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "NPJ Vaccines"
DOI: 10.1038/s41541-022-00438-4
Abstract: Acellular pertussis (aP) booster vaccines are central to pertussis immunization programs, although their effectiveness varies. The Bacille Calmette-Guérin (BCG) vaccine is a prototype inducer of trained immunity, which enhances immune responses to subsequent infections or… read more here.
Keywords: pertussis; vaccination; trained immunity; bcg ... See more keywords