Trained innate immunity: a salient factor in the pathogenesis of neuroimmune psychiatric disorders
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.186
Abstract: Historically, only cells of the adaptive immune system have been considered capable of retaining memory for infectious challenges. Recently, however, cells of the innate immune system have been shown to be capable of displaying long-term… read more here.
Keywords: trained innate; innate immunity; immune system; innate immune ... See more keywords
Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation.
Sign Up to like & getrecommendations! Published in 2021 at "Transplantation"
DOI: 10.1097/tp.0000000000003673
Abstract: While significant progress has been made to improve short-term survival of transplant patients, long-term acceptance of allografts in solid organ and hematopoietic stem cell (HSC) transplantation is still a significant challenge. Current therapeutics for preventing… read more here.
Keywords: trained innate; innate immune; solid organ; transplantation ... See more keywords
Irreversible Electroporation and β-Glucan Induced Trained Innate Immunity for the Treatment of Pancreatic Ductal Adenocarcinoma: A Phase II Study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American College of Surgeons"
DOI: 10.1097/xcs.0000000000001291
Abstract: INTRODUCTION Irreversible electroporation(IRE) has augmented the effects of certain immunotherapies in pancreatic cancer(PDA). Yeast-derived particulate beta-glucan induces trained innate immunity and has successfully reduces murine PC tumor burden. This is a Phase II study to… read more here.
Keywords: trained innate; immunity; irreversible electroporation; ire ... See more keywords
Efficacy of Candida dubliniensis and Fungal β-Glucans in Inducing Trained Innate Immune Protection Against Inducers of Sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.898030
Abstract: Fungal-bacterial intra-abdominal infections (IAI) can lead to sepsis with significant morbidity and mortality. We have established a murine model of Candida albicans (Ca) and Staphylococcus aureus (Sa) IAI that results in acute lethal sepsis. Prior… read more here.
Keywords: sepsis; trained innate; protection; immunization ... See more keywords
Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2024.1500772
Abstract: Preeclampsia (PE) is a complex pregnancy syndrome characterized by hypertension with or without proteinuria, affecting 2–6% of pregnancies globally. PE is characterized by excessive release of damage-associated molecular patterns (DAMPs) into the maternal circulation. This… read more here.
Keywords: disease; trained innate; innate immunity; link ... See more keywords
Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00013
Abstract: Objective: Damage and pathogen associated molecular patterns such as oxidized low-density lipoprotein (oxLDL) or bacillus Calmette-Guerin (BCG) vaccine can induce long term pro-inflammatory priming in monocytes and macrophages due to metabolic and epigenetic reprogramming—an emerging… read more here.
Keywords: trained innate; innate immunity; smooth muscle; muscle cells ... See more keywords
Learning to Be Elite: Lessons From HIV-1 Controllers and Animal Models on Trained Innate Immunity and Virus Suppression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.858383
Abstract: Although antiretroviral therapy (ART) has drastically changed the lives of people living with human immunodeficiency virus-1 (HIV-1), long-term treatment has been associated with a vast array of comorbidities. Therefore, a cure for HIV-1 remains the… read more here.
Keywords: trained innate; hiv; animal models; innate immune ... See more keywords
Trained Innate Immunity Not Always Amicable
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102565
Abstract: The concept of “trained innate immunity” is understood as the ability of innate immune cells to remember invading agents and to respond nonspecifically to reinfection with increased strength. Trained immunity is orchestrated by epigenetic modifications… read more here.
Keywords: immunity; innate immune; always amicable; immunity always ... See more keywords