Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum
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DOI: 10.1128/msphere.00755-21
Abstract: Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening malaria, yet the molecular mechanisms that underlie HbAS protection from severe malaria remain incompletely understood. Here, we used transcriptome sequencing (RNA-seq) to measure the impact… read more here.
Keywords: protection; protection severe; plasmodium falciparum; trait hemoglobin ... See more keywords
Sickle-trait hemoglobin reduces adhesion to both CD36 and EPCR by Plasmodium falciparum-infected erythrocytes
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DOI: 10.1371/journal.ppat.1009659
Abstract: Sickle-trait hemoglobin protects against severe Plasmodium falciparum malaria. Severe malaria is governed in part by the expression of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) that are encoded by var genes, specifically those variants… read more here.
Keywords: sickle trait; trait; adhesion; plasmodium falciparum ... See more keywords