Trajectories from single-cells to PAX5-driven leukemia reveal PAX5-MYC interplay in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02626-2
Abstract: PAX5 acts as a master regulator of B-cell proliferation and differentiation. Its germline and somatic deregulation have both been implicated in the development of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, the process how reduced… read more here.
Keywords: bcp; pax5; trajectories single; pre leukemic ... See more keywords
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09670-4
Abstract: Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic… read more here.
Keywords: single cell; trajectories single; stream; cell transcriptomic ... See more keywords