Effect of tramadol hydrochloride on neural tube development in 48-hr chick embryos: Argyrophilic nucleolar organizing region and genetic analysis study.
Sign Up to like & getrecommendations! Published in 2022 at "Birth defects research"
DOI: 10.1002/bdr2.2137
Abstract: BACKGROUND Tramadol hydrochloride or tramadol is an opioid analgesic that acts on the central nervous system. The pregnancy category of tramadol is determined as "C" according to the Food and Drug Administration. There are no… read more here.
Keywords: neural tube; tramadol; tramadol hydrochloride; chick embryos ... See more keywords
Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ‐opioid receptor
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21973
Abstract: Tramadol is a synthetic opioid with centrally acting analgesic activity that alleviates moderate to severe pain and treats withdrawal symptoms of the other opioids. Like other opioid drugs, tramadol abuse has adverse effects on central… read more here.
Keywords: apoptosis synaptogenesis; effect; tramadol; hippocampal neurons ... See more keywords
Intracerebral microdialysis coupled to LC-MS/MS for the determination tramadol and its major pharmacologically active metabolite O-desmethyltramadol in rat brain microdialysates.
Sign Up to like & getrecommendations! Published in 2017 at "Drug testing and analysis"
DOI: 10.1002/dta.2157
Abstract: A rapid and sensitive method involving liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) coupled to an intracerebral microdialysis technique was developed for the determination and pharmacokinetic investigation of tramadol and its major active metabolite O-desmethyltramadol… read more here.
Keywords: rat brain; microdialysis; intracerebral microdialysis; tramadol ... See more keywords
Automated High-Throughput Analysis of Tramadol and O-Desmethyltramadol in Dried Blood Spots.
Sign Up to like & getrecommendations! Published in 2020 at "Drug testing and analysis"
DOI: 10.1002/dta.2819
Abstract: The World Anti-Doping Agency (WADA) and the International Testing Agency (ITA) recently announced the development and implementation of dried blood spot (DBS) testing for routine analysis in time for the 2022 Winter Olympic and Paralympic… read more here.
Keywords: tramadol; analysis; analysis tramadol; tramadol desmethyltramadol ... See more keywords
Association between tramadol use and risk of pneumonia in the middle‐aged and elderly populations: a propensity‐score matched cohort study
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.1943
Abstract: Tramadol is a widely used weak opioid; however, the evidence for its safety profile in respiratory system needs additional information. We aimed to examine whether tramadol use is associated with an increased risk of pneumonia… read more here.
Keywords: tramadol; tramadol use; risk pneumonia;
Tramadol use in Norway: A register‐based population study
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4626
Abstract: Increasing use of tramadol for chronic non‐cancer pain is concerning since tramadol users may be at risk of developing recurrent opioid use with increasing opioid consumption and co‐medication. Therefore, we investigated a complete national cohort… read more here.
Keywords: use; tramadol; use norway; register based ... See more keywords
Tramadol dispensing patterns and trends in Canada, 2007‐2016
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4679
Abstract: Opioid use and associated mortality and morbidity have substantially increased in Canada, which recent interventions have aimed to reduce. Tramadol is an atypical prescription‐only (but unscheduled under Canada's narcotics law) opioid analgesic and not subject… read more here.
Keywords: tramadol dispensing; tramadol; dispensing patterns; patterns trends ... See more keywords
Effect of tramadol and DOACs with special attention to dabigatran on concomitant use, on the risk of mayor bleeding using BIFAP database in Spain
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5525
Abstract: Tramadol, a weak opioid, inhibits the reuptake of serotonin, a key feature on vascular homeostasis. A suspected interaction exists between dabigatran and tramadol, which might trigger an excess on risk of bleeding however, there is… read more here.
Keywords: tramadol doacs; special attention; doacs special; tramadol ... See more keywords
Oral tramadol versus oral celecoxib for analgesia after mediolateral episiotomy repair in obese primigravidae: a randomized controlled trial
Sign Up to like & getrecommendations! Published in 2020 at "International Urogynecology Journal"
DOI: 10.1007/s00192-020-04411-4
Abstract: A variety of pharmacological and non-pharmacological interventions have been investigated, with the goal of relieving pain after post-episiotomy repair. We aimed to compare the efficacy of tramadol versus celecoxib orally in reducing pain after mediolateral… read more here.
Keywords: tramadol; episiotomy repair; group; mediolateral episiotomy ... See more keywords
Vomiting and constipation associated with tramadol and codeine: a comparative study in VigiBase®
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2536-z
Abstract: The most frequent adverse drug reactions (ADRs) of codeine and tramadol, the two main step 2 opioid analgesics, include nausea, dizziness, sedation, vomiting, and constipation [1]. The relative importance of vomiting and constipation remains discussed… read more here.
Keywords: codeine; tramadol; vigibase; study ... See more keywords
A pharmacokinetic drug-drug interaction study between pregabalin and tramadol in healthy volunteers
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2543-0
Abstract: PurposeCombination therapy of pregabalin and tramadol is used to treat chronic neuropathic pain; however, the pharmacokinetic (PK) interactions of these drugs has not been studied. This study aimed to evaluate PK interactions between pregabalin and… read more here.
Keywords: pregabalin tramadol; tramadol; study; drug ... See more keywords