Phase I study of trametinib with neoadjuvant chemoradiation (CRT) in patients with locally advanced rectal cancers (LARC).
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DOI: 10.1200/jco.2017.35.15_suppl.3612
Abstract: 3612Background: The RAS/RAF/MEK signal transduction pathway is critical to the development of colorectal cancer, and tumors harboring KRAS, NRAS, and BRAF mutations were shown to be resistant to ra... read more here.
Keywords: crt patients; neoadjuvant chemoradiation; study trametinib; trametinib neoadjuvant ... See more keywords