Overexpression of SOD2/MnSOD promotes tumor growth and poor prognosis in TRAMP mice
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.222
Abstract: Mitochondrial superoxide dismutase (SOD2/MnSOD) is a primary line of antioxidant defense. Under aerobic conditions, its role detoxifying superoxide into H2O2 is crucial, as deduced from the early death of SOD2-/- KO mice after birth. SOD2… read more here.
Keywords: sod2; tramp mice; mice; tumor growth ... See more keywords
Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized 13C-SIRA.
Sign Up to like & getrecommendations! Published in 2021 at "Talanta"
DOI: 10.1016/j.talanta.2021.122812
Abstract: Hyperpolarized 13C isotope resolved spectroscopy boosts NMR signal intensity, which improves signal detection and allows metabolic fluxes to be analyzed. Such hyperpolarized flux data may offer new approaches to tissue classification and biomarker identification that… read more here.
Keywords: prostate; classification; tramp mice; tissue ... See more keywords
MALAT1 Fusions and Basal Cells Contribute to Primary Resistance against Androgen Receptor Inhibition in TRAMP Mice
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14030749
Abstract: Simple Summary We deeply characterized a frequently used mouse model of prostate cancer and found cellular and molecular regulators of resistance against antihormonal treatment, such as basal cell function and MALAT1 gene fusions. As these… read more here.
Keywords: primary resistance; tramp mice; cell; resistance ... See more keywords