The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22983
Abstract: Tranilast, N-(3',4'-dimethoxycinnamoyl)-anthranilic acid, is an anti-allergic drug and is considered for use in the treatment of rheumatoid arthritis. Methotrexate, an antimetabolite and folate antagonist to treat some cancers, is also a first-line drug for RA.… read more here.
Keywords: mtx; drug drug; drug; methotrexate ... See more keywords
Design and synthesis of novel tranilast analogs: Docking, antiproliferative evaluation and in-silico screening of TGFβR1 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104368
Abstract: The discovery of the antiproliferative potential of tranilast prompted additional studies directed at understanding the mechanisms of tranilast action. Its inhibitory effect on cell proliferation depends principally on the capacity of tranilast to interfere with… read more here.
Keywords: design synthesis; novel tranilast; tgf inhibitors; tranilast analogs ... See more keywords
Tranilast prevents doxorubicin-induced myocardial hypertrophy and angiotensin II synthesis in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118984
Abstract: An increase in oxidative stress is an important pathological mechanism of heart injury induced by doxorubicin (DOX). Tranilast is an anti-allergy drug that has been shown to possess good antioxidant activity in previous studies. The… read more here.
Keywords: tranilast; hypertrophy; angiotensin; dox ... See more keywords
Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46140
Abstract: Accumulation of mechanical stresses during cancer progression can induce blood and lymphatic vessel compression, creating hypo-perfusion, hypoxia and interstitial hypertension which decrease the efficacy of chemo- and nanotherapies. Stress alleviation treatment has been recently proposed… read more here.
Keywords: tranilast; efficacy; efficacy chemo; improves efficacy ... See more keywords
Tranilast and Minocycline Combination for Intractable Severe Acne and Prevention of Postacne Scarring: A Case Series.
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000001160
Abstract: To the Editor: Patients with severe acne1 are greatly afflicted by cosmetic problems due to postacne scarring1,2 that can impair their quality of life. Severe acne1 is characterized by cysts, nodules, or nodulocystic lesions in… read more here.
Keywords: acne; combination; treatment; severe acne ... See more keywords
Tranilast Inhibits Genes Functionally Involved in Cell Proliferation, Fibrosis, and Epigenetic Regulation and Epigenetically Induces miR-29c Expression in Leiomyoma Cells
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DOI: 10.1177/1933719116682878
Abstract: Tranilast (N-3,4-dimethoxycinnamoyl anthranilic acid) is an antiallergic agent with inhibitory effects on cell proliferation and extracellular matrix production. Here we assess the effect of tranilast on the expression of miR-29c and genes functionally involved in… read more here.
Keywords: cell proliferation; tranilast; mir 29c; expression ... See more keywords
Tranilast attenuates lipopolysaccharide-induced lung injury via the CXCR4/JAK2/STAT3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12736
Abstract: It has been reported that the expression of C-X-C motif chemokine receptor 4 (CXCR4) is increased in patients with lung injury, while CXCR4 downregulation can improve sepsis-induced lung injury. Previous studies have shown that tranilast… read more here.
Keywords: lung injury; stat3 signaling; jak2 stat3; cxcr4 ... See more keywords