Articles with "tranilast analogs" as a keyword



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Design and synthesis of novel tranilast analogs: Docking, antiproliferative evaluation and in-silico screening of TGFβR1 inhibitors.

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Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.104368

Abstract: The discovery of the antiproliferative potential of tranilast prompted additional studies directed at understanding the mechanisms of tranilast action. Its inhibitory effect on cell proliferation depends principally on the capacity of tranilast to interfere with… read more here.

Keywords: design synthesis; novel tranilast; tgf inhibitors; tranilast analogs ... See more keywords