Asymmetric aminoarylation for the synthesis of trans-3-amino-4-aryltetrahydroquinolines: An access to aza-analogue of dihydrexidine
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DOI: 10.1016/j.tet.2021.132257
Abstract: Abstract The N-sulfonyl spiroaziridine oxindole is a recently developed versetile precusor in synthesis of wide range of 3,3-disubstitued/spirooxindoles. It usually prepared in three steps from isatin and needs costly and limited available sulfinimides and hazardous… read more here.
Keywords: trans amino; synthesis; synthesis trans; aminoarylation synthesis ... See more keywords
Convenient synthesis of trans-3-amino-1-benzylpiperidin-4-ols using regiospecific cleavage of 1-benzyl-3,4-epoxypiperidine with diisobutylaluminum amides (DIBAL-NR1R2)
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DOI: 10.1016/j.tetlet.2017.04.017
Abstract: Abstract The report presents a first example of a regio- and stereospecific Lewis acid-catalyzed aminolysis of 1-benzyl-3,4-epoxypiperidine leading to trans -3-amino-1-benzylpiperidin-4-ols, in contrast with other Lewis acid-catalyzed reactions leading to trans -4-amino-1-benzylpiperidin-3-ols. The reaction is… read more here.
Keywords: benzylpiperidin ols; trans amino; benzyl epoxypiperidine; amino benzylpiperidin ... See more keywords