Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia
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DOI: 10.1038/s41375-021-01465-1
Abstract: TO THE EDITOR: In a large trans-ethnic meta-analysis GWAS of childhood acute lymphoblastic leukemia (ALL), we identified three putatively novel susceptibility loci (MYB/HBS1L, TET1, and NRBF2/JMJD1C) and two additional independent risk associations at previously reported… read more here.
Keywords: risk; susceptibility; childhood; analysis ... See more keywords
Trans-ethnic genome-wide association study of severe COVID-19
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DOI: 10.1038/s42003-021-02549-5
Abstract: COVID-19 has caused numerous infections with diverse clinical symptoms. To identify human genetic variants contributing to the clinical development of COVID-19, we genotyped 1457 (598/859 with severe/mild symptoms) and sequenced 1141 (severe/mild: 474/667) patients of… read more here.
Keywords: genome wide; covid; severe covid; wide association ... See more keywords
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
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DOI: 10.1186/s13073-021-00877-z
Abstract: Background DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this… read more here.
Keywords: kidney; ethnic ethnic; trans ethnic; kidney function ... See more keywords
Discovery and fine-mapping of loci associated with MUFAs through trans-ethnic meta-analysis in Chinese and European populations[S]
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DOI: 10.1194/jlr.p071860
Abstract: MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D,… read more here.
Keywords: chinese european; ethnic meta; meta; acid ... See more keywords