Design of Nanohydrogels for Targeted Intracellular Drug Transport to the Trans‐Golgi Network
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201794
Abstract: Nanohydrogels combine advantages of hydrogels and nanoparticles. In particular, they represent promising drug delivery systems. Nanogel synthesis by oxidative condensation of polyglycidol prepolymers, that are modified with thiol groups, results in crosslinking by disulfide bonds.… read more here.
Keywords: trans golgi; microscopy; rs1 reg; drug ... See more keywords
Isolation and Glycomic Analysis of Trans-Golgi Network Vesicles in Plants.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0767-1_13
Abstract: The dynamic endomembrane system facilitates sorting and transport of diverse cargo. Therefore, it is crucial for plant growth and development. Vesicle proteomic studies have made substantial progress in recent years. In contrast, much less is… read more here.
Keywords: glycomic analysis; vesicle; isolation glycomic; golgi network ... See more keywords
Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.10.012
Abstract: How the principal functions of the Golgi apparatus-protein processing, lipid synthesis, and sorting of macromolecules-are integrated to constitute cargo-specific trafficking pathways originating from the trans-Golgi network (TGN) is unknown. Here, we show that the activity of… read more here.
Keywords: golgi network; trans golgi; spca1 calcium; synthesis sorting ... See more keywords
Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.11.011
Abstract: Objective Intracellular vesicle trafficking maintains cellular structures and functions. The assembly of cargo-laden vesicles at the trans-Golgi network is initiated by the ARF family of small GTPases. Here, we demonstrate the role of the trans-Golgi… read more here.
Keywords: insulin; trafficking; trans golgi; insulin receptor ... See more keywords
YIPF1, YIPF2, and YIPF6 are medial‐/trans‐Golgi and trans‐Golgi network‐localized Yip domain family proteins, which play a role in the Golgi reassembly and glycan synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.03.011
Abstract: ABSTRACT In this study, we attempted to explore the function of three uncharacterized mammalian homologs of yeast Yip domain family proteins—YIPF6, a homolog of Yip1p, and YIPF1 and YIPF2, which are homologs of Yif1p. Immunofluorescence… read more here.
Keywords: medial trans; trans golgi; yipf2 yipf6; yipf1 yipf2 ... See more keywords
Benzyl alcohol induces a reversible fragmentation of the Golgi apparatus and inhibits membrane trafficking between endosomes and the trans‐Golgi network
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.04.025
Abstract: ABSTRACT Benzyl alcohol (BnOH) is widely used as a component of foods, cosmetics, household products and medical products. It is generally considered to be safe for human use, however, it has been connected to a… read more here.
Keywords: golgi network; trans golgi; benzyl alcohol; alcohol ... See more keywords
Trans-Golgi network breaks away to activate NLRP3
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Immunology"
DOI: 10.1038/s41577-018-0111-6
Abstract: NLRP3 activators cause disassembly of the trans-Golgi network, and the dispersed trans-Golgi network serves as a scaffold for NLRP3 inflammasome assembly and activation. read more here.
Keywords: away activate; network breaks; golgi network; trans golgi ... See more keywords
The Trans Golgi Region is a Labile Intracellular Ca2+ Store Sensitive to Emetine
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35280-z
Abstract: The Golgi apparatus (GA) is a bona fide Ca2+ store; however, there is a lack of GA-specific Ca2+ mobilizing agents. Here, we report that emetine specifically releases Ca2+ from GA in HeLa and HL-1 atrial… read more here.
Keywords: emetine; trans golgi; ca2 store; golgi region ... See more keywords
Rab6 is required for rapid, cisternal-specific, intra-Golgi cargo transport
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73276-w
Abstract: Rab6, the most abundant Golgi associated small GTPase, consists of 2 equally common isoforms, Rab6A and Rab6A′, that differ in 3 amino acids and localize to trans Golgi cisternae. The two isoforms are largely redundant… read more here.
Keywords: trans golgi; golgi; transport; rab6 ... See more keywords
Exploring new routes for secretory protein export from the trans-Golgi network
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-02-0117
Abstract: Sorting of soluble proteins for transport to intracellular compartments and for secretion from cells is essential for cell and tissue homeostasis. The trans-Golgi network (TGN) is a major sorting station that sorts secretory proteins into… read more here.
Keywords: exploring new; golgi network; trans golgi; routes secretory ... See more keywords
A Golgi-Released Subpopulation of the Trans-Golgi Network Mediates Protein Secretion in Arabidopsis1[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Physiology"
DOI: 10.1104/pp.18.01228
Abstract: The Golgi-released independent trans-Golgi network mediates the protein secretory pathway that is needed for extracellular delivery of cell wall-modification enzymes. Spatiotemporal coordination of protein trafficking among organelles is essential for eukaryotic cells. The post-Golgi interface,… read more here.
Keywords: golgi network; trans golgi; network mediates; mediates protein ... See more keywords