Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species
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DOI: 10.1126/sciadv.add7969
Abstract: RAS-ERK (extracellular signal–regulated kinase) pathway signals are modulated by scaffold proteins that assemble the components of different kinase tiers into a sequential phosphorylation cascade. In the prevailing model scaffold proteins function as isolated entities, where… read more here.
Keywords: trans phosphorylation; scaffold protein; scaffold proteins; kinase ... See more keywords
Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation
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DOI: 10.18632/oncotarget.24058
Abstract: Despite intensive research no therapies targeted against the oncogenic EGFRvIII are present in the clinic. One of the reasons is the elusive nature of the molecular structure and activity of the truncated receptor. The recent… read more here.
Keywords: trans phosphorylation; type egfr; mutant receptor; receptor ... See more keywords