IL‐1/IL‐1R signaling induced by all‐trans‐retinal contributes to complement alternative pathway activation in retinal pigment epithelium
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30103
Abstract: The underlying mechanisms of complement activation in Stargardt disease type 1 (STGD1) and age‐related macular degeneration (AMD) are not fully understood. Overaccumulation of all‐trans‐retinal (atRAL) has been proposed as the pathogenic factor in both diseases.… read more here.
Keywords: complement alternative; alternative pathway; rpe cells; activation ... See more keywords
All-trans-retinal as a modulator of metabolic and mitochondrial signatures in non-tumorigenic and malignant breast cells: a Raman-based approach
Sign Up to like & getrecommendations! Published in 2025 at "Mikrochimica Acta"
DOI: 10.1007/s00604-025-07571-6
Abstract: Retinoids are well recognized for their therapeutic potential in pharmacy and medicine. Although extensively studied for their anticancer properties, the specific effects of all-trans-retinal (ALTR) on the metabolism of breast cancer cells—particularly in relation to… read more here.
Keywords: spectroscopy; malignant breast; non tumorigenic; trans retinal ... See more keywords
Ultrasound-Enhanced Delivery of Doxorubicin-Loaded Nanodiamonds from Pullulan-all-trans-Retinal Nanoparticles for Effective Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b03559
Abstract: Nanodiamond as a drug carrier is of great significance in improving cancer therapy by overcoming chemoresistance. However, its clinical application is severely limited because of insufficient tumor vascular penetration. To address this limitation, pullulan-all-trans-retinal (pullulan-ATR)… read more here.
Keywords: pullulan trans; doxorubicin loaded; cancer; cancer therapy ... See more keywords
Multistep 11-cis to All-trans Retinal Photoisomerization in Bestrhodopsin, an Unusual Microbial Rhodopsin
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c06216
Abstract: Rhodopsins constitute a broad class of retinal-binding photoreceptors. Microbial rhodopsins are canonically activated through an all-trans to 13-cis photoisomerization, whereas animal rhodopsins are mostly activated through an 11-cis to all-trans isomerization. Bestrhodopsins constitute a special… read more here.
Keywords: photoisomerization; microbial rhodopsin; cis; cis trans ... See more keywords
Targeted therapy of atherosclerosis by pH-sensitive hyaluronic acid nanoparticles co-delivering all-trans retinal and rapamycin.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr06514a
Abstract: Atherosclerosis, the leading cause of death in the elderly worldwide, is typically characterized by elevated reactive oxygen species (ROS) levels and a chronic inflammatory state at the arterial plaques. Herein, pH-sensitive nanoparticles (HRRAP NPs) co-delivering… read more here.
Keywords: trans retinal; delivering trans; hrrap nps; atherosclerosis ... See more keywords
Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinal.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2023.02.04
Abstract: AIM To study the effect of palmitoylethanolamide (PEA) on apoptosis of retinal pigment epithelial (RPE) cells induced by all-trans retinal (atRAL) and to explore the possible molecular mechanism. METHODS CellTiter 96® Aqueous One Solution Cell… read more here.
Keywords: cell; trans retinal; effect; induced trans ... See more keywords