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Published in 2022 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2022.104372
Abstract: Interleukin-6 (IL-6) is a pleiotropic inflammatory cytokine, which plays a dual role in mammalian inflammation through both classical signaling (IL-6 binds to IL-6 receptor/IL-6R) and trans-signaling (IL-6 binds to soluble IL-6R). However, the function of…
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Keywords:
mail trans;
iron metabolism;
trans signaling;
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Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.09.009
Abstract: ABSTRACT Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Recently, Interleukin‐6 (IL‐6) trans‐signaling via soluble IL‐6 receptor (sIL‐6R) has emerged as a prominent regulator of inflammation in endothelial cells. This study…
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Keywords:
inflammation;
trans signaling;
barrier disruption;
endothelial cells ... See more keywords
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Published in 2017 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.7b00208
Abstract: Trans-signaling of the major pro- and anti-inflammatory cytokines Interleukin (IL)-6 and IL-11 has the unique feature to virtually activate all cells of the body and is critically involved in chronic inflammation and regeneration. Hyper-IL-6 and…
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Keywords:
split2 protein;
cytokine;
hyper;
trans signaling ... See more keywords
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1
Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.3hi0517-198r
Abstract: Ly6C+ monocytes are important components of the innate immune defense against infections. These cells have been shown to proliferate in the bone marrow of mice with systemic infections. However, the proliferative capacity of Ly6C+ monocytes…
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Keywords:
proliferation ly6c;
trans signaling;
ly6c monocytes;
ly6c ... See more keywords
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2
Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1097606
Abstract: For most, staying “mentally sharp” as they age is a very high priority that may be thwarted by the consequences of a postoperative complication unrelated to the disorder which necessitated the surgical intervention. Perioperative neurocognitive…
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Keywords:
perioperative neurocognitive;
defining role;
trans signaling;
clinical trials ... See more keywords
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2
Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12050681
Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several mechanisms, and the alteration of IL-6 signaling leads to the overactivation of various processes including immunity, inflammation, and hemostasis. Although IL-6 increase has been documented in…
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Keywords:
trans signaling;
asp358ala variant;
dvt patients;
dvt ... See more keywords
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Published in 2019 at "Theranostics"
DOI: 10.7150/thno.32352
Abstract: Rationale: Renal fibrosis is the terminal manifestation of chronic and irreversible renal disease. Effective therapies other than dialysis are extremely limited. In this study, we investigated the potential effects of targeting elevated interleukin-6 (IL-6) levels…
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Keywords:
fibrosis;
blocking interleukin;
trans signaling;
renal fibrosis ... See more keywords