Articles with "trans signaling" as a keyword



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The effects of blunt snout bream (Megalobrama amblycephala) IL-6 trans-signaling on immunity and iron metabolism via JAK/STAT3 pathway.

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Published in 2022 at "Developmental and comparative immunology"

DOI: 10.1016/j.dci.2022.104372

Abstract: Interleukin-6 (IL-6) is a pleiotropic inflammatory cytokine, which plays a dual role in mammalian inflammation through both classical signaling (IL-6 binds to IL-6 receptor/IL-6R) and trans-signaling (IL-6 binds to soluble IL-6R). However, the function of… read more here.

Keywords: mail trans; iron metabolism; trans signaling;
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Inhibition of interleukin‐6 trans‐signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells

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Published in 2019 at "Experimental Eye Research"

DOI: 10.1016/j.exer.2018.09.009

Abstract: ABSTRACT Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Recently, Interleukin‐6 (IL‐6) trans‐signaling via soluble IL‐6 receptor (sIL‐6R) has emerged as a prominent regulator of inflammation in endothelial cells. This study… read more here.

Keywords: inflammation; trans signaling; barrier disruption; endothelial cells ... See more keywords
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Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors.

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Published in 2017 at "ACS synthetic biology"

DOI: 10.1021/acssynbio.7b00208

Abstract: Trans-signaling of the major pro- and anti-inflammatory cytokines Interleukin (IL)-6 and IL-11 has the unique feature to virtually activate all cells of the body and is critically involved in chronic inflammation and regeneration. Hyper-IL-6 and… read more here.

Keywords: split2 protein; cytokine; hyper; trans signaling ... See more keywords
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Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL‐6 trans‐signaling

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Published in 2018 at "Journal of Leukocyte Biology"

DOI: 10.1189/jlb.3hi0517-198r

Abstract: Ly6C+ monocytes are important components of the innate immune defense against infections. These cells have been shown to proliferate in the bone marrow of mice with systemic infections. However, the proliferative capacity of Ly6C+ monocytes… read more here.

Keywords: proliferation ly6c; trans signaling; ly6c monocytes; ly6c ... See more keywords
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Defining the role of Interleukin-6 for the development of perioperative neurocognitive disorders: Evidence from clinical and preclinical studies

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Published in 2023 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2022.1097606

Abstract: For most, staying “mentally sharp” as they age is a very high priority that may be thwarted by the consequences of a postoperative complication unrelated to the disorder which necessitated the surgical intervention. Perioperative neurocognitive… read more here.

Keywords: perioperative neurocognitive; defining role; trans signaling; clinical trials ... See more keywords
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Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients

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Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12050681

Abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several mechanisms, and the alteration of IL-6 signaling leads to the overactivation of various processes including immunity, inflammation, and hemostasis. Although IL-6 increase has been documented in… read more here.

Keywords: trans signaling; asp358ala variant; dvt patients; dvt ... See more keywords
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Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation

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Published in 2019 at "Theranostics"

DOI: 10.7150/thno.32352

Abstract: Rationale: Renal fibrosis is the terminal manifestation of chronic and irreversible renal disease. Effective therapies other than dialysis are extremely limited. In this study, we investigated the potential effects of targeting elevated interleukin-6 (IL-6) levels… read more here.

Keywords: fibrosis; blocking interleukin; trans signaling; renal fibrosis ... See more keywords