Preparation of 2,3-trans-substituted piperidines from optically active β-amino-α-methylene esters: Synthesis of optically active (2S,3R)-(−)-epi-CP-99,994
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DOI: 10.1016/j.tet.2017.06.054
Abstract: Abstract Chiral 2,3- trans -substituted piperidines were readily prepared in three steps from β-amino-α-methylene esters, which were prepared by the Michael/Mannich domino reaction of chiral sulfinimines. Hydrogenation of the N -tosyl-2-aryl-1,2,5,6-tetrahydropyridine intermediates took place smoothly… read more here.
Keywords: optically active; synthesis optically; trans substituted; methylene esters ... See more keywords