Trans‐Synaptic Degeneration Following Acute Optic Neuritis in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26529
Abstract: To explore longitudinal changes in brain volumetric measures and retinal layer thicknesses following acute optic neuritis (AON) in people with multiple sclerosis (PwMS), to investigate the process of trans‐synaptic degeneration, and determine its clinical relevance. read more here.
Keywords: acute optic; following acute; trans synaptic; optic neuritis ... See more keywords
Trans‐synaptic mechanisms orchestrated by mammalian synaptic cell adhesion molecules
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200134
Abstract: Bidirectional trans‐synaptic signaling is essential for the formation, maturation, and plasticity of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in shaping the identities of trans‐synaptic signaling pathways. A series of recent studies… read more here.
Keywords: cell adhesion; adhesion molecules; trans synaptic; synaptic cell ... See more keywords
Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.09.027
Abstract: Summary Fine orchestration of excitatory and inhibitory synaptic development is required for normal brain function, and alterations may cause neurodevelopmental disorders. Using sparse molecular manipulations in intact brain circuits, we show that the glutamate receptor… read more here.
Keywords: receptor delta; glutamate receptor; pyramidal neurons; cortical pyramidal ... See more keywords
Trans-synaptic LGI1–ADAM22–MAGUK in AMPA and NMDA receptor regulation
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108628
Abstract: Exquisitely-regulated synaptic transmission and plasticity underlie higher brain functions such as learning and memory. PSD-95, a member of the MAGUK family, scaffolds an array of postsynaptic proteins including AMPA and NMDA receptors, and plays essential… read more here.
Keywords: receptor; ampa nmda; lgi1 adam22; trans synaptic ... See more keywords
Dysregulated Neurotransmission induces Trans-synaptic degeneration in reconstructed Neuronal Networks
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DOI: 10.1038/s41598-018-29918-1
Abstract: Increasing evidence suggests that pathological hallmarks of chronic degenerative syndromes progressively spread among interconnected brain areas in a disease-specific stereotyped pattern. Functional brain imaging from patients affected by various neurological syndromes such as traumatic brain… read more here.
Keywords: dysregulated neurotransmission; brain; neuronal networks; trans synaptic ... See more keywords
Excitatory and inhibitory receptors utilize distinct post- and trans-synaptic mechanisms in vivo
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.59613
Abstract: Ionotropic neurotransmitter receptors at postsynapses mediate fast synaptic transmission upon binding of the neurotransmitter. Post- and trans-synaptic mechanisms through cytosolic, membrane, and secreted proteins have been proposed to localize neurotransmitter receptors at postsynapses. However, it… read more here.
Keywords: trans synaptic; synaptic mechanisms; neurotransmitter receptors; excitatory inhibitory ... See more keywords