Abstract 4145: TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27 transactivating FOSL1 and promoting the ubiquitination of p27
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DOI: 10.1158/1538-7445.am2025-4145
Abstract: Our previous studies demonstrated that FOSL1 promotes glioblastoma (GBM) progression and stemness through multiple pathways such as STAT3 and NF-κB signaling. Recently, we identified that FOSL1 physically interacts with the E3 ligaseTRIM21, which is localized… read more here.
Keywords: ubiquitination; transactivating fosl1; p27; trim21 ... See more keywords