Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-019-00527-5
Abstract: Protease activated receptors (PARs) transactivate both epidermal growth factor receptors (EGFR) and transforming growth factor (TGF)-β receptors (TGFBR1) in vascular smooth muscle leading to the increased expression of genes (CHST11 and CHSY1) which are rate… read more here.
Keywords: phosphorylation; transactivation; linker region; smad linker ... See more keywords
Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro
Sign Up to like & getrecommendations! Published in 2019 at "Exposure and Health"
DOI: 10.1007/s12403-019-00318-8
Abstract: Perfluoroalkyl acids (PFAAs) are detectable in human blood. PFAA exposure may contribute to androgen receptor (AR)-related health effects such as prostate cancer (PCa). In Norway and Sweden, exposures to PFAAs and PCa are very real… read more here.
Keywords: exposure levels; transactivation; exposure; translocation ... See more keywords
Induction of AhR transactivation by PBDD/Fs and PCDD/Fs using a novel human-relevant, high-throughput DRhuman CALUX reporter gene assay.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.128086
Abstract: Polychlorinated dioxins and dibenzofurans (PCDD/Fs) are highly toxic contaminants that are strictly regulated and monitored in the environment and food to reduce human exposure. Recently, the increasing occurrence of polybrominated dioxins and dibenzofurans (PBDD/Fs) in… read more here.
Keywords: human relevant; transactivation; reporter gene; ahr ... See more keywords
A novel MAF missense mutation leads to congenital nuclear cataract by impacting the transactivation of crystallin and noncrystallin genes.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.01.011
Abstract: The transcription factor v-maf avain musculoaponeurotic fibrosarcoma oncogene homolog (MAF) plays an important role in lens development. It contains a unique extended homology region (EHR) in the DNA binding domain. MAF mutations are associated with… read more here.
Keywords: transactivation; maf; cataract; congenital nuclear ... See more keywords
A Tunable and Expandable Transactivation System in Probiotic Yeast Saccharomyces boulardii.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00384
Abstract: Precise transcriptional modulation is a key requirement for developing synthetic probiotics with predictably tunable functionalities. In this study, an expandable and tunable transactivation system was constructed and validated in probiotic yeast Saccharomyces boulardii. The use… read more here.
Keywords: system; transactivation; promoter; transactivation system ... See more keywords
Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40810-4
Abstract: A previously identified enhancer 10 kb upstream of the Aggrecan (Acan) gene (UE) can drive cartilage specific reporter expression in vivo. Here, we report that the paralogous transcription factors PAX1 and PAX9 differentially drive UE, depending… read more here.
Keywords: transactivation; sox9 driven; driven transactivation; upstream aggrecan ... See more keywords
Structural basis to characterise transactivation domain of BRCA1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2015.1136896
Abstract: Familial inheritance of breast and ovarian cancer is attributed to mutations discovered in functional domains of BRCA1 gene. BRCA1 is a multifunctional protein responsible for maintaining the genomic integrity and has transcriptional regulatory function encoded… read more here.
Keywords: structural basis; transactivation; basis characterise; characterise transactivation ... See more keywords
Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14279
Abstract: The tumor suppressor gene p53 encodes a transcriptional activator that has two transactivation domains (TAD) located in its amino terminus. These two TAD can transactivate genes independently, and at least one TAD is required for… read more here.
Keywords: transactivation; target genes; binding sequences; p53 ... See more keywords
Transactivation of Sus1 and Sus2 by Opaque2 is an essential supplement to sucrose synthase‐mediated endosperm filling in maize
Sign Up to like & getrecommendations! Published in 2020 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13349
Abstract: Summary The endosperm‐specific transcription factor Opaque2 (O2) acts as a central regulator for endosperm filling, but its functions have not been fully defined. Regular o2 mutants exhibit a non‐vitreous phenotype, so we used its vitreous… read more here.
Keywords: sus1 sus2; seed; transactivation; sucrose synthase ... See more keywords
Formyl Peptide Receptor 1 Modulates Endothelial Cell Functions by NADPH Oxidase-Dependent VEGFR2 Transactivation
Sign Up to like & getrecommendations! Published in 2018 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2018/2609847
Abstract: In the vasculature, NADPH oxidase is the main contributor of reactive oxygen species (ROS) which play a key role in endothelial signalling and functions. We demonstrate that ECV304 cells express p47phox, p67phox, and p22phox subunits… read more here.
Keywords: oxidase dependent; transactivation; vegfr2 transactivation; nadph oxidase ... See more keywords
Sphingosine 1-Phosphate-Upregulated COX-2/PGE2 System Contributes to Human Cardiac Fibroblast Apoptosis: Involvement of MMP-9-Dependent Transactivation of EGFR Cascade
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7664290
Abstract: Human cardiac fibroblasts (HCFs) play key roles in normal physiological functions and pathological processes in the heart. Our recent study has found that, in HCFs, sphingosine 1-phosphate (S1P) can upregulate the expression of cyclooxygenase-2 (COX-2)… read more here.
Keywords: pge2 system; cox pge2; transactivation; cox ... See more keywords