EGFR‐HER2 Transactivation Viewed in Space and Time Through the Versatile Spectacles of Imaging Cytometry—Implications for Targeted Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Cytometry Part A"
DOI: 10.1002/cyto.a.24922
Abstract: Ligand‐induced formation of signaling platforms composed of homo‐ and/or heterodimers of receptor tyrosine kinases is considered essential for their activation and consequential contribution to the progression of many cancers. Epidermal Growth Factor Receptor (EGFR) acts… read more here.
Keywords: receptor; time; her2; transactivation ... See more keywords
Diversity of transactivation regions of DMRT1 in vertebrates
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology Reports"
DOI: 10.1007/s11033-024-10006-9
Abstract: Doublesex and mab-3 related transcription factor (DMRT) 1, commonly found in all vertebrates, regulates the transcription of genes involved in the masculinization and maintenance of gonadal somatic cells and/or germline cell development. DMRT1 has a… read more here.
Keywords: transactivation regions; diversity transactivation; transactivation; regions dmrt1 ... See more keywords
Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-019-00527-5
Abstract: Protease activated receptors (PARs) transactivate both epidermal growth factor receptors (EGFR) and transforming growth factor (TGF)-β receptors (TGFBR1) in vascular smooth muscle leading to the increased expression of genes (CHST11 and CHSY1) which are rate… read more here.
Keywords: phosphorylation; transactivation; linker region; smad linker ... See more keywords
Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro
Sign Up to like & getrecommendations! Published in 2019 at "Exposure and Health"
DOI: 10.1007/s12403-019-00318-8
Abstract: Perfluoroalkyl acids (PFAAs) are detectable in human blood. PFAA exposure may contribute to androgen receptor (AR)-related health effects such as prostate cancer (PCa). In Norway and Sweden, exposures to PFAAs and PCa are very real… read more here.
Keywords: exposure levels; transactivation; exposure; translocation ... See more keywords
Induction of AhR transactivation by PBDD/Fs and PCDD/Fs using a novel human-relevant, high-throughput DRhuman CALUX reporter gene assay.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.128086
Abstract: Polychlorinated dioxins and dibenzofurans (PCDD/Fs) are highly toxic contaminants that are strictly regulated and monitored in the environment and food to reduce human exposure. Recently, the increasing occurrence of polybrominated dioxins and dibenzofurans (PBDD/Fs) in… read more here.
Keywords: human relevant; transactivation; reporter gene; ahr ... See more keywords
A novel MAF missense mutation leads to congenital nuclear cataract by impacting the transactivation of crystallin and noncrystallin genes.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.01.011
Abstract: The transcription factor v-maf avain musculoaponeurotic fibrosarcoma oncogene homolog (MAF) plays an important role in lens development. It contains a unique extended homology region (EHR) in the DNA binding domain. MAF mutations are associated with… read more here.
Keywords: transactivation; maf; cataract; congenital nuclear ... See more keywords
A Tunable and Expandable Transactivation System in Probiotic Yeast Saccharomyces boulardii.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00384
Abstract: Precise transcriptional modulation is a key requirement for developing synthetic probiotics with predictably tunable functionalities. In this study, an expandable and tunable transactivation system was constructed and validated in probiotic yeast Saccharomyces boulardii. The use… read more here.
Keywords: system; transactivation; promoter; transactivation system ... See more keywords
Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40810-4
Abstract: A previously identified enhancer 10 kb upstream of the Aggrecan (Acan) gene (UE) can drive cartilage specific reporter expression in vivo. Here, we report that the paralogous transcription factors PAX1 and PAX9 differentially drive UE, depending… read more here.
Keywords: transactivation; sox9 driven; driven transactivation; upstream aggrecan ... See more keywords
SNX16 aggravates AngII-induced cardiac hypertrophy in mice via EGFR transactivation.
Sign Up to like & getrecommendations! Published in 2025 at "Communications biology"
DOI: 10.1038/s42003-025-09243-w
Abstract: Cardiac hypertrophy is an independent risk factor for heart failure (HF) which often leads to cardiovascular disease-related death worldwide. Here we show that the upregulated expressions of Sorting Nexin 16 (SNX16) are evident in the… read more here.
Keywords: cardiac hypertrophy; hypertrophy; induced cardiac; transactivation ... See more keywords
Structural basis to characterise transactivation domain of BRCA1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2015.1136896
Abstract: Familial inheritance of breast and ovarian cancer is attributed to mutations discovered in functional domains of BRCA1 gene. BRCA1 is a multifunctional protein responsible for maintaining the genomic integrity and has transcriptional regulatory function encoded… read more here.
Keywords: structural basis; transactivation; basis characterise; characterise transactivation ... See more keywords
Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14279
Abstract: The tumor suppressor gene p53 encodes a transcriptional activator that has two transactivation domains (TAD) located in its amino terminus. These two TAD can transactivate genes independently, and at least one TAD is required for… read more here.
Keywords: transactivation; target genes; binding sequences; p53 ... See more keywords