Transactivation Domain of Human c-Myc Is Essential to Alleviate Poly(Q)-Mediated Neurotoxicity in Drosophila Disease Models
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0910-4
Abstract: Polyglutamine (poly(Q)) disorders, such as Huntington’s disease (HD) and spinocerebellar ataxias, represent a group of neurological disorders which arise due to an atypically expanded poly(Q) tract in the coding region of the affected gene. Pathogenesis… read more here.
Keywords: poly; poly mediated; transactivation domain; mediated neurotoxicity ... See more keywords
Regulation of Androgen Receptor Activity by Transient Interactions of Its Transactivation Domain with General Transcription Regulators.
Sign Up to like & getrecommendations! Published in 2018 at "Structure"
DOI: 10.1016/j.str.2017.11.007
Abstract: The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of… read more here.
Keywords: transcription; androgen receptor; general transcription; transactivation domain ... See more keywords
Foxi3 transcription factor activity is mediated by a C-terminal transactivation domain and regulated by the Protein Phosphatase 2A (PP2A) complex
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35390-8
Abstract: The Forkhead box (FOX) family consists of at least 19 subgroups of transcription factors which are characterized by the presence of an evolutionary conserved ‘forkhead’ or ‘winged-helix’ DNA-binding domain. Despite having a conserved core DNA… read more here.
Keywords: terminal transactivation; foxi3; transactivation domain; protein phosphatase ... See more keywords
Structural basis to characterise transactivation domain of BRCA1
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DOI: 10.1080/07391102.2015.1136896
Abstract: Familial inheritance of breast and ovarian cancer is attributed to mutations discovered in functional domains of BRCA1 gene. BRCA1 is a multifunctional protein responsible for maintaining the genomic integrity and has transcriptional regulatory function encoded… read more here.
Keywords: structural basis; transactivation; basis characterise; characterise transactivation ... See more keywords
A cryptic transactivation domain of EZH2 binds AR and AR’s splice variant, promoting oncogene activation and tumorous transformation
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac861
Abstract: Enhancer of Zeste Homolog 2 (EZH2) and androgen receptor (AR) are crucial chromatin regulators involved in the development and/or progression of prostate tumor, including advanced castration-resistant prostate cancer (CRPC). To sustain prostate tumorigenicity, EZH2 establishes… read more here.
Keywords: activation; ezh2; cryptic transactivation; transactivation domain ... See more keywords