Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b01070
Abstract: Human tissue transglutaminase (hTG2) is a multifunctional enzyme. It is primarily known for its calcium-dependent transamidation activity that leads to formation of an isopeptide bond between glutamine and lysine residues found on the surface of… read more here.
Keywords: human tissue; targeted covalent; tissue transglutaminase; gtp binding ... See more keywords
Nickel/Briphos-Catalyzed Direct Transamidation of Unactivated Secondary Amides Using Trimethylsilyl Chloride.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03304
Abstract: Direct transamidation of secondary amides was developed via nickel catalysis. In the presence of trimethylsilyl chloride and manganese, Ni(diglyme)Cl2 with a Briphos ligand efficiently promoted the transamidation of N-aryl benzamide derivatives with primary amines to… read more here.
Keywords: nickel briphos; trimethylsilyl chloride; secondary amides; direct transamidation ... See more keywords
Nickel-Catalyzed Reductive Transamidation of Secondary Amides with Nitroarenes
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DOI: 10.1021/acscatal.7b02859
Abstract: Transmidation is an attractive method for amide synthesis. However, transamidation of secondary amides is challenging. Here, we describe a reductive transamidation method that employs readily available nitro(hetero)arenes as the nitrogen sources, zinc or manganese as… read more here.
Keywords: transamidation secondary; reductive transamidation; secondary amides; catalyzed reductive ... See more keywords
Transamidation-Driven Molecular Pumps
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DOI: 10.1021/jacs.2c06807
Abstract: We report a new class of synthetic molecular pumps that use a stepwise information ratchet mechanism to achieve the kinetic gating required to sequester their macrocyclic substrates from bulk solution. Threading occurs as a result… read more here.
Keywords: transamidation; rotaxane; transamidation driven; pump ... See more keywords
Highly selective transition-metal-free transamidation of amides and amidation of esters at room temperature
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DOI: 10.1038/s41467-018-06623-1
Abstract: Amide chemistry has an essential role in the synthesis of high value molecules, such as pharmaceuticals, natural products, and fine chemicals. Over the past years, several examples of transamidation reactions have been reported. In general,… read more here.
Keywords: amides amidation; transition metal; metal; transamidation amides ... See more keywords
N-Acylcarbazole as a Selective Transamidation Reagent
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20200116
Abstract: N-acylation reaction offers an opportunity to develop an efficient synthesis of amide group-containing molecules. We found that N-acyl carbazoles showed remarkable selectivity in transamidation. St... read more here.
Keywords: acylcarbazole selective; transamidation; transamidation reagent; selective transamidation ... See more keywords