Driving Transamination Irreversible by Decomposing Byproduct α-Ketoglutarate into Ethylene Using Ethylene-Forming Enzyme
Sign Up to like & getrecommendations! Published in 2018 at "Catalysis Letters"
DOI: 10.1007/s10562-018-2552-8
Abstract: The transformations of transaminases have been extensively studied as an approach to the production of chiral amino moieties. However, the low equilibrium conversion of the reaction is a critical disadvantage to transaminase application, and a… read more here.
Keywords: byproduct ketoglutarate; transamination; using ethylene; ketoglutarate ethylene ... See more keywords
Vitamin B6-Based Biomimetic Asymmetric Catalysis.
Sign Up to like & getrecommendations! Published in 2023 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.3c00053
Abstract: ConspectusOne of the fundamental goals of chemists is to develop highly efficient methods for producing optically active compounds, given their wide range of applications in chemistry, pharmaceutical industry, chemical biology, and material science. Biomimetic asymmetric… read more here.
Keywords: transamination; catalysis; biomimetic asymmetric; asymmetric catalysis ... See more keywords
Cryptic Oxidative Transamination of Hydroxynaphthoquinone in Natural Product Biosynthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13074
Abstract: Pyridoxal 5'-phosphate (PLP)-dependent enzymes are a group of versatile enzymes that catalyze various reactions, but only a small number of them react with O2. Here, we report an unprecedented PLP-dependent enzyme, NphE, that catalyzes both… read more here.
Keywords: transamination; biosynthesis; cryptic oxidative; transamination hydroxynaphthoquinone ... See more keywords
BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.247957
Abstract: In response to environmental stimuli, macrophages change their nutrient consumption and undergo an early metabolic adaptation that progressively shapes their polarization state. During the transient, early phase of pro-inflammatory macrophage activation, an increase in tricarboxylic… read more here.
Keywords: transamination; bcat1; tca cycle; activation ... See more keywords
Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0008928
Abstract: Amino acid metabolism within Trypanosoma brucei, the causative agent of human African trypanosomiasis, is critical for parasite survival and virulence. Of these metabolic processes, the transamination of aromatic amino acids is one of the most… read more here.
Keywords: transamination; essential transamination; tryptophan derivatives; trypanosoma brucei ... See more keywords