Identification of a non-competitive inhibitor of Plasmodium falciparum aspartate transcarbamoylase.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.112
Abstract: Aspartate transcarbamoylase catalyzes the second step of de-novo pyrimidine biosynthesis. As malarial parasites lack pyrimidine salvage machinery and rely on de-novo production for growth and proliferation, this pathway is a target for drug discovery. Previously,… read more here.
Keywords: transcarbamoylase; plasmodium falciparum; aspartate transcarbamoylase;
Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.841833
Abstract: Malaria remains one of the most prominent and dangerous tropical diseases. While artemisinin and analogs have been used as first-line drugs for the past decades, due to the high mutational rate and rapid adaptation to… read more here.
Keywords: aspartate transcarbamoylase; transcarbamoylase; drug; aspartate ... See more keywords