Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Brain Stimulation"
DOI: 10.1016/j.brs.2020.03.016
Abstract: OBJECTIVE Iaccarino et al. (2016) [1] exposed 1 h of light flickering at 40 Hz to awake 5XFAD Alzheimer's Disease (AD) mouse models, generating action potentials at 40 Hz, activating ∼54% of microglia to colocalize with Aβ plaque, acutely,… read more here.
Keywords: focused ultrasound; iaccarino 2016; transcranial focused; ultrasound pulsed ... See more keywords
Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22743-7
Abstract: Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct modulation effects in different neuron populations, then the mechanism can be understood through… read more here.
Keywords: focused ultrasound; transcranial focused; neuron; functional neuron ... See more keywords
Numerical evaluation of the skull for human neuromodulation with transcranial focused ultrasound.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neural engineering"
DOI: 10.1088/1741-2552/aa843e
Abstract: OBJECTIVE Transcranial focused ultrasound is an emerging field for human non-invasive neuromodulation, but its dosing in humans is difficult to know due to the skull. The objective of the present study was to establish modeling… read more here.
Keywords: focused ultrasound; transcranial focused; skull; pressure maps ... See more keywords
Transcranial Focused Ultrasound Stimulation of Periaqueductal Gray for Analgesia
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Biomedical Engineering"
DOI: 10.1109/tbme.2022.3162073
Abstract: Objective: Transcranial focused ultrasound (tFUS) is regarded as a promising non-invasive stimulation tool for modulating brain circuits. The aim of this study is to explore the feasibility of tFUS stimulation for analgesia applications. Methods: 50… read more here.
Keywords: periaqueductal gray; analgesia; focused ultrasound; tfus stimulation ... See more keywords
Suppressing Grating Lobes for Transcranial Focused Ultrasound System by Frequency-Modulated Excitation
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control"
DOI: 10.1109/tuffc.2020.3047664
Abstract: Transcranial focused ultrasound is a novel noninvasive therapeutic modality for glioblastoma and other disorders of the brain. However, because the phase aberrations caused by the skull need to be corrected with computed tomography (CT) images,… read more here.
Keywords: frequency; excitation; focus; grating lobes ... See more keywords
Implication of Auditory Confounding in Interpreting Somatosensory and Motor Responses in Low-Intensity Transcranial Focused Ultrasound Stimulation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurophysiology"
DOI: 10.1152/jn.00701.2020
Abstract: Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a non-invasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous… read more here.
Keywords: focused ultrasound; transcranial focused; intensity transcranial; stimulation ... See more keywords
Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Human Neuroscience"
DOI: 10.3389/fnhum.2021.749162
Abstract: Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical… read more here.
Keywords: focused ultrasound; inhibitory effects; transcranial focused; excitatory inhibitory ... See more keywords
Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer’s Disease: A Preliminary Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12020250
Abstract: Preclinical studies have suggested that low-intensity transcranial focused ultrasound (tFUS) may have therapeutic potential for Alzheimer’s disease (AD) by opening the blood–brain barrier (BBB), reducing amyloid pathology, and improving cognition. This study investigated the effects… read more here.
Keywords: focused ultrasound; alzheimer disease; hippocampus; transcranial focused ... See more keywords
Offline impact of transcranial focused ultrasound on cortical activation in primates
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.40541
Abstract: To understand brain circuits it is necessary both to record and manipulate their activity. Transcranial ultrasound stimulation (TUS) is a promising non-invasive brain stimulation technique. To date, investigations report short-lived neuromodulatory effects, but to deliver… read more here.
Keywords: tus; activation; offline impact; impact transcranial ... See more keywords