The value of primary transcripts to the clinical and non-clinical genomics community: Survey results and roadmap for improvements.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular genetics & genomic medicine"
DOI: 10.1002/mgg3.1786
Abstract: BACKGROUND Variant interpretation is dependent on transcript annotation and remains time consuming and challenging. There are major obstacles for historical data reuse and for interpretation of new variants. First, both RefSeq and Ensembl/GENCODE produce transcript… read more here.
Keywords: interpretation; community; survey; primary transcripts ... See more keywords
Expression Analysis of BDNF, BACE1, and Their Natural Occurring Antisenses in Autistic Patients
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-019-01432-7
Abstract: Autism spectrum disorder (ASD) as a multifaceted neurological syndrome affects many aspects of neuropsychologic functions. Dysregulated expressions of several genes have been documented in ASD patients. The current project aimed at comparison of transcript levels… read more here.
Keywords: age; transcript levels; natural occurring; bace1 natural ... See more keywords
Impact of Alternative Splicing on the Human Proteome
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.07.025
Abstract: Summary Alternative splicing is a critical determinant of genome complexity and, by implication, is assumed to engender proteomic diversity. This notion has not been experimentally tested in a targeted, quantitative manner. Here, we have developed… read more here.
Keywords: impact alternative; splicing human; impact; human proteome ... See more keywords
Comprehensive expression profiling reveals the possible involvement of Cullins in developmental and stress regulation in rice
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2019.01.008
Abstract: Abstract In eukaryotes, the Cullin proteins, particularly Cullin-4, are well-known for their role in mediating protein ubiquitination in combination with diverse cellular components that form complexes called E3 ligases or Cullin-RING Ligases (CRLs). In a… read more here.
Keywords: rice; stress treatments; regulation; stress regulation ... See more keywords
CBL4-CIPK5 pathway confers salt but not drought and chilling tolerance by regulating ion homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "Environmental and Experimental Botany"
DOI: 10.1016/j.envexpbot.2020.104230
Abstract: Abstract Calcineurin B-like protein (CBL) and CBL-interacting protein kinase (CIPK) play an important role in regulation on plant abiotic stress tolerance. It is unknown whether CBL-CIPK pathway regulates abiotic stress tolerance in bermudagrass. In the… read more here.
Keywords: oshkt1 oshkt1; tolerance; pathway confers; cdtcipk5 ... See more keywords
Identification and expression analysis of alternatively spliced new transcript isoform of Bax gene in mouse.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2017.04.020
Abstract: Bax, a pro-apoptotic member of Bcl-2 family regulates apoptosis through homodimerization/heterodimerization with Bcl-2. Bax-α is the only product of the Bax gene that has been extensively studied. Bax-α exists in inactive form and several conformational… read more here.
Keywords: new transcript; transcript; transcript variant; bax gene ... See more keywords
Analysis of two transcript isoforms of vacuolar ATPase subunit H in mouse and zebrafish.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.09.065
Abstract: ATP6V1H encodes the subunit H of vacuolar ATPase (V-ATPase) and has been recently proved to regulate osteoclast function. The alternative splicing of ATP6V1H gene results in two isoforms, and it is not clear whether and… read more here.
Keywords: atpase; two isoforms; analysis; vacuolar atpase ... See more keywords
Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.01.006
Abstract: Summary RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymerase-associated factor 1 (Paf1), but it is not known… read more here.
Keywords: transcript; elongation; transcription elongation; fate ... See more keywords
Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.01.027
Abstract: Summary The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A key player in this process is the cleavage and polyadenylation (CPA) factor PCF11, which directly binds to the Pol II… read more here.
Keywords: seq; roles vertebrate; pcf11; selective roles ... See more keywords
The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2022.113009
Abstract: LINC010503 is a novel oncogenic lncRNA in multiple cancers. In this study, we further explored the expression of LINC010503 transcripts and their regulations on the glioblastoma (GBM) stem cell (GSC) properties. LINC01503 transcription patterns in… read more here.
Keywords: gli2; cells via; transcript; cell ... See more keywords
Insight into the Tumor Suppression Mechanism from the Structure of Human Polypyrimidine Splicing Factor (PSF/SFPQ) Complexed with a 30mer RNA from Murine Virus-like 30S Transcript-1.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00192
Abstract: Human polypyrimidine-binding splicing factor (PSF/SFPQ) is a tumor suppressor protein that regulates the gene expression of several proto-oncogenes and binds to the 5'-polyuridine negative-sense template (5'-PUN) of some RNA viruses. The activity of PSF is… read more here.
Keywords: structure; human polypyrimidine; transcript; rna ... See more keywords