Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology"
DOI: 10.1186/s13059-020-02071-7
Abstract: High-throughput single-cell RNA-seq (scRNA-seq) is a powerful tool for studying gene expression in single cells. Most current scRNA-seq bioinformatics tools focus on analysing overall expression levels, largely ignoring alternative mRNA isoform expression. We present a… read more here.
Keywords: seq; cell; transcript usage; differential transcript ... See more keywords
satuRn: Scalable analysis of differential transcript usage for bulk and single-cell RNA-sequencing applications
Sign Up to like & getrecommendations! Published in 2021 at "F1000Research"
DOI: 10.12688/f1000research.51749.1
Abstract: Alternative splicing produces multiple functional transcripts from a single gene. Dysregulation of splicing is known to be associated with disease and as a hallmark of cancer. Existing tools for differential transcript usage (DTU) analysis either… read more here.
Keywords: transcript usage; differential transcript; saturn scalable; analysis ... See more keywords
Pregnancy induces extensive changes of transcript usage in the goat brain.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of dairy science"
DOI: 10.3168/jds.2025-26608
Abstract: Gestation induces strong anatomical, histological and transcriptomic changes in the pregnant female brain. Our study aimed to characterize the RNA transcripts expressed in the goat brain and their main structural, transcriptional, and functional features, while… read more here.
Keywords: brain pregnancy; transcript usage; brain; goat brain ... See more keywords
Genetic effects on promoter usage are highly context-specific and contribute to complex traits
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.41673
Abstract: Genetic variants regulating RNA splicing and transcript usage have been implicated in both common and rare diseases. Although transcript usage quantitative trait loci (tuQTLs) have been mapped across multiple cell types and contexts, it is… read more here.
Keywords: transcript usage; promoter usage; usage; complex traits ... See more keywords