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   Articles with "transcriptase" as a keyword



Approaches to repurposing reverse transcriptase antivirals in cancer

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recommendations! Published in 2025 at "British Journal of Clinical Pharmacology"

DOI: 10.1002/bcp.70113

Abstract: This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.… read more here.

Keywords: cytotoxicity cancer; cell; transcriptase; reverse transcriptase ... See more keywords

Reverse transcriptase loop-mediated isothermal amplification and reverse transcriptase recombinase amplification assays for rapid and sensitive detection of cardamom vein clearing virus

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recommendations! Published in 2020 at "3 Biotech"

DOI: 10.1007/s13205-020-02238-w

Abstract: In the present study, two isothermal molecular assays viz . reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) and reverse transcriptase recombinase amplification (RT-RPA) were developed to detect the cardamom vein clearing virus (CdVCV) infecting cardamom. Assays… read more here.

Keywords: cardamom; pcr; transcriptase; reverse transcriptase ... See more keywords

Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme.

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recommendations! Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2019.111987

Abstract: Infection by human immunodeficiency virus still represents a continuous serious concern and a global threat to human health. Due to appearance of multi-resistant virus strains and the serious adverse side effects of the antiretroviral therapy… read more here.

Keywords: quinoxaline compounds; hiv; transcriptase; transcriptase enzyme ... See more keywords

Dual inhibitor design for HIV-1 reverse transcriptase and integrase enzymes: a molecular docking study

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recommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"

DOI: 10.1080/07391102.2019.1700166

Abstract: Abstract HIV-1, a member of Retroviruses’ Lentivirus family, is the causative agent of AIDS. The virus is common throughout the world and leaves the body vulnerable to infections by suppressing the human immune system. Reverse… read more here.

Keywords: reverse transcriptase; transcriptase; transcriptase integrase; design ... See more keywords

Proposal of pharmacophore model for HIV reverse transcriptase inhibitors: Combined mutational effect analysis, molecular dynamics, molecular docking and pharmacophore modeling study

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recommendations! Published in 2024 at "International Journal of Immunopathology and Pharmacology"

DOI: 10.1177/03946320241231465

Abstract: Objectives: Antiretroviral therapy (ART) efficacy is jeopardized by the emergence of drug resistance mutations in HIV, compromising treatment effectiveness. This study aims to propose novel analogs of Effavirenz (EFV) as potential direct inhibitors of HIV… read more here.

Keywords: analysis; pharmacophore model; transcriptase; reverse transcriptase ... See more keywords

Resistance levels to non-nucleoside reverse transcriptase inhibitors among pregnant women with recent HIV infection in Malawi

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recommendations! Published in 2022 at "Antiviral therapy"

DOI: 10.1177/13596535221121225

Abstract: Background Information on HIV drug resistance (HIVDR) prevalence in people newly diagnosed with HIV is limited. We implemented a cross-sectional study to estimate HIVDR prevalence among pregnant women recently infected with HIV in Malawi. Methods… read more here.

Keywords: reverse transcriptase; infection; pregnant women; transcriptase inhibitors ... See more keywords

Me-Better Drug Design Based on Nevirapine and Mechanism of Molecular Interactions with Y188C Mutant HIV-1 Reverse Transcriptase

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27217348

Abstract: In this paper, the Y188C mutant HIV-1 reverse transcriptase (Y188CM-RT) target protein was constructed by homology modeling, and new ligands based on nevirapine (NVP) skeleton were designed by means of fragment growth. The binding activity… read more here.

Keywords: hiv reverse; transcriptase; y188c mutant; reverse transcriptase ... See more keywords

Patterns of Reverse Transcriptase Inhibitor Resistance Mutations in People Living with Human Immunodeficiency Virus in Libreville, Gabon

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recommendations! Published in 2025 at "Tropical Medicine and Infectious Disease"

DOI: 10.3390/tropicalmed10080216

Abstract: Objective: To characterize the profiles of resistance mutations to HIV reverse transcriptase inhibitors in Gabon. Design: Cross-sectional study conducted over 37 months, from October 2019 to October 2022, at the IST/HIV/AIDS Reference Laboratory, a reference… read more here.

Keywords: virus; transcriptase; reverse transcriptase; resistance mutations ... See more keywords