Reverse transcriptase loop-mediated isothermal amplification and reverse transcriptase recombinase amplification assays for rapid and sensitive detection of cardamom vein clearing virus
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DOI: 10.1007/s13205-020-02238-w
Abstract: In the present study, two isothermal molecular assays viz . reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) and reverse transcriptase recombinase amplification (RT-RPA) were developed to detect the cardamom vein clearing virus (CdVCV) infecting cardamom. Assays… read more here.
Keywords: cardamom; pcr; transcriptase; reverse transcriptase ... See more keywords
Design, synthesis and biological evaluation of quinoxaline compounds as anti-HIV agents targeting reverse transcriptase enzyme.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111987
Abstract: Infection by human immunodeficiency virus still represents a continuous serious concern and a global threat to human health. Due to appearance of multi-resistant virus strains and the serious adverse side effects of the antiretroviral therapy… read more here.
Keywords: quinoxaline compounds; hiv; transcriptase; transcriptase enzyme ... See more keywords
Dual inhibitor design for HIV-1 reverse transcriptase and integrase enzymes: a molecular docking study
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DOI: 10.1080/07391102.2019.1700166
Abstract: Abstract HIV-1, a member of Retroviruses’ Lentivirus family, is the causative agent of AIDS. The virus is common throughout the world and leaves the body vulnerable to infections by suppressing the human immune system. Reverse… read more here.
Keywords: reverse transcriptase; transcriptase; transcriptase integrase; design ... See more keywords
Resistance levels to non-nucleoside reverse transcriptase inhibitors among pregnant women with recent HIV infection in Malawi
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DOI: 10.1177/13596535221121225
Abstract: Background Information on HIV drug resistance (HIVDR) prevalence in people newly diagnosed with HIV is limited. We implemented a cross-sectional study to estimate HIVDR prevalence among pregnant women recently infected with HIV in Malawi. Methods… read more here.
Keywords: reverse transcriptase; infection; pregnant women; transcriptase inhibitors ... See more keywords
Me-Better Drug Design Based on Nevirapine and Mechanism of Molecular Interactions with Y188C Mutant HIV-1 Reverse Transcriptase
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DOI: 10.3390/molecules27217348
Abstract: In this paper, the Y188C mutant HIV-1 reverse transcriptase (Y188CM-RT) target protein was constructed by homology modeling, and new ligands based on nevirapine (NVP) skeleton were designed by means of fragment growth. The binding activity… read more here.
Keywords: hiv reverse; transcriptase; y188c mutant; reverse transcriptase ... See more keywords