Synthesis and Characterization of Specific Reverse Transcriptase Inhibitors for Mammalian LINE-1 Retrotransposons.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.04.010
Abstract: Retrotransposons are a type of transposable element (TE) that have amplified to astonishing numbers in mammalian genomes, comprising more than a third of the human and mouse genomes. Long interspersed element class 1 (LINE-1 or… read more here.
Keywords: line; transcriptase inhibitors; line retrotransposons; mammalian line ... See more keywords
Scorpion-Shaped Zinc Porphyrins as Tetrafunctional TAR RNA Predators and HIV-1 Reverse Transcriptase Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c00975
Abstract: HIV-1 reverse transcriptase (RT) inhibitors are fundamental to the discovery and development of anti-HIV drugs. Their main target is RT, and only a tiny number of them can bind to viral RNA. In this paper,… read more here.
Keywords: reverse transcriptase; hiv reverse; tar rna; rna ... See more keywords
Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Communications Chemistry"
DOI: 10.1038/s42004-019-0174-8
Abstract: HIV-1 reverse transcriptase offers a key target for antiviral therapy. However, the rapid emergence of drug-resistant mutations in reverse transcriptase as well as the poor pharmacokinetic properties of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) limits… read more here.
Keywords: transcriptase inhibitors; nucleoside reverse; reverse; non nucleoside ... See more keywords
Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213146119
Abstract: Significance The role of endogenous retrotransposons in cancer initiation and progression has been traditionally viewed in the context of their mutagenic activity. The main conclusion of the present work is that retrotransposons can stimulate treatment… read more here.
Keywords: inflammatory response; transcriptase inhibitors; resistance; reverse transcriptase ... See more keywords
Ritonavir-Boosted Darunavir Plus Two Nucleoside Reverse Transcriptase Inhibitors versus Other Regimens for Initial Antiretroviral Therapy for People with HIV Infection: A Systematic Review
Sign Up to like & getrecommendations! Published in 2017 at "AIDS Research and Treatment"
DOI: 10.1155/2017/2345617
Abstract: Background Darunavir is a second-generation protease-inhibitor used with ritonavir (DRV/r) and two nucleoside reverse-transcriptase inhibitors as an option in first-line antiretroviral treatment (ART). Methods We systematically reviewed randomized controlled trials (RCTs) of DRV/r versus other… read more here.
Keywords: transcriptase inhibitors; ritonavir boosted; nucleoside reverse; ritonavir ... See more keywords
Resistance levels to non-nucleoside reverse transcriptase inhibitors among pregnant women with recent HIV infection in Malawi
Sign Up to like & getrecommendations! Published in 2022 at "Antiviral therapy"
DOI: 10.1177/13596535221121225
Abstract: Background Information on HIV drug resistance (HIVDR) prevalence in people newly diagnosed with HIV is limited. We implemented a cross-sectional study to estimate HIVDR prevalence among pregnant women recently infected with HIV in Malawi. Methods… read more here.
Keywords: reverse transcriptase; infection; pregnant women; transcriptase inhibitors ... See more keywords
Nucleotide Reverse Transcriptase Inhibitors: A Thorough Review, Present Status and Future Perspective as HIV Therapeutics.
Sign Up to like & getrecommendations! Published in 2017 at "Current HIV research"
DOI: 10.2174/1570162x15666171120110145
Abstract: BACKGROUND Human immunodeficiency virus type-1 (HIV-1) infection leads to acquired immunodeficiency syndrome (AIDS), a severe viral infection that has claimed approximately 658,507 lives in the US between the years 2010-2014. Antiretroviral (ARV) therapy has proven… read more here.
Keywords: transcriptase inhibitors; hiv; infection; pharmacology ... See more keywords
In vitro effect of some nucleoside reverse transcriptase inhibitors against HSV-1 replication.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202002_20204
Abstract: OBJECTIVE The current study was designed to investigate the effects of some nucleoside reverse transcriptase inhibitors (NRTIs) on HSV-1 infection. MATERIALS AND METHODS Initially, the SwissTargetPrediction server was used to predict the interactions between HSV-1… read more here.
Keywords: transcriptase inhibitors; nucleoside reverse; reverse transcriptase; replication ... See more keywords
Synthesis and molecular docking studies of quinoline derivatives as HIV non-nucleoside reverse transcriptase inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Turkish Journal of Chemistry"
DOI: 10.3906/kim-2004-14
Abstract: Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the… read more here.
Keywords: transcriptase inhibitors; nucleoside reverse; non nucleoside; reverse transcriptase ... See more keywords