Dual inhibitor design for HIV-1 reverse transcriptase and integrase enzymes: a molecular docking study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1700166
Abstract: Abstract HIV-1, a member of Retroviruses’ Lentivirus family, is the causative agent of AIDS. The virus is common throughout the world and leaves the body vulnerable to infections by suppressing the human immune system. Reverse… read more here.
Keywords: reverse transcriptase; transcriptase; transcriptase integrase; design ... See more keywords
Dual HIV-1 reverse transcriptase and integrase inhibitors from Limonium morisianum Arrigoni, an endemic species of Sardinia (Italy)
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1434649
Abstract: Abstract During our search for potential templates of HIV-1 reverse transcriptase (RT) and integrase (IN) dual inhibitors, the methanolic extract obtained from aerial parts of Limonium morisianum was investigated. Repeated bioassay-guided chromatographic purifications led to… read more here.
Keywords: reverse transcriptase; limonium morisianum; transcriptase integrase; hiv reverse ... See more keywords
Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
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DOI: 10.3390/v15010031
Abstract: Reverse transcriptase (RT) and integrase (IN) are encoded tandemly in the pol genes of retroviruses. We reported recently that HIV-1 RT and IN need to be supplied as the pol precursor intermediates, in which RT… read more here.
Keywords: cis allosteric; hiv; reverse transcriptase; transcriptase integrase ... See more keywords