Derepression of matrix metalloproteinase gene transcription and an emphysema‐like phenotype in transcription factor Zbtb7c knockout mouse lungs
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13501
Abstract: Dysregulated matrix metalloproteinase (MMP) gene expression is a major cause of the degradation of lung tissue that is integral to emphysema pathogenesis. Cigarette smoking (CS) increases MMP gene expression, a major contributor to emphysema development.… read more here.
Keywords: mouse lungs; transcription; zbtb7c; matrix metalloproteinase ... See more keywords
Transcription factor EB controls both motogenic and mitogenic cell activities
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14442
Abstract: Transcription factor EB (TFEB) belongs to the microphthalmia family of bHLH‐leucine zipper transcription factors and was first identified as an oncogene in a subset of renal cell carcinomas. In addition to exhibiting oncogenic activity, TFEB… read more here.
Keywords: cell; transcription; factor controls; transcription factor ... See more keywords
RNA polymerase efficiently transcribes through DNA‐scaffolded, cooperative bacteriophage repressor complexes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14447
Abstract: DNA can act as a scaffold for the cooperative binding of protein oligomers. For example, the phage 186 CI repressor forms a wheel of seven dimers wrapped in DNA with specific binding sites, while phage… read more here.
Keywords: dna; repressor; transcription; rna polymerase ... See more keywords
EGFR transcription in non-small-cell lung cancer tumours can be revealed in ctDNA by cell-free chromatin immunoprecipitation (cfChIP).
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13093
Abstract: Determination of tumour-specific transcription based on liquid biopsies possesses a large diagnostic and prognostic potential in non-small cell lung cancer (NSCLC). Cell-free DNA (cfDNA) packed in nucleosomes mirrors the histone modification profiles present in the… read more here.
Keywords: transcription; cell free; cfchip; egfr l858r ... See more keywords
Induction of ubiquitin C (UBC) gene transcription is mediated by HSF1: role of proteotoxic and oxidative stress
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12484
Abstract: The polyubiquitin gene ubiquitin C (UBC) is considered a stress protective gene and is upregulated under various stressful conditions, which is probably a consequence of an increased demand for ubiquitin in order to remove toxic… read more here.
Keywords: transcription; ubc gene; factor; stress ... See more keywords
Set2‐mediated H3K36 methylation states redundantly repress the production of antisense transcripts: role in transcription regulation
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13226
Abstract: Methyltransferase Set2‐mediated methylation of histone H3 lysine 36 (H3K36), which involves the addition of up to three methyl groups at this site, has been demonstrated to function in many chromatin‐coupled events. The methylation of H3K36… read more here.
Keywords: methylation; transcription; production antisense; antisense transcripts ... See more keywords
LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103135
Abstract: Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents. Identification… read more here.
Keywords: circular dna; hbv; transcription; covalently closed ... See more keywords
A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201166
Abstract: Cancer stem cells (CSCs) are reported to play essential roles in chemoresistance and metastasis. Pathways regulating CSC self‐renewal and proliferation, such as Hedgehog, Notch, Wnt/β‐catenin, TGF‐β, and Myc, may be potential therapeutic targets. Here, a… read more here.
Keywords: inhibition; transcription; cancer stem; functional screening ... See more keywords
Effect of G-quadruplex loop mutations on the G-quadruplex formation, protein binding and transcription of BmPOUM2 in Bombyx mori.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21876
Abstract: A G-quadruplex (G4) was identified in the promoter of transcription factor BmPOUM2 in Bombyx mori. This G4 structure contains three loops and is bound by transcription factor BmLARK, facilitating the transcription of BmPOUM2. However, the… read more here.
Keywords: bmpoum2 bombyx; loop; structure; transcription ... See more keywords
Chromatin priming elements establish immunological memory in T cells without activating transcription
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DOI: 10.1002/bies.201600184
Abstract: We have identified a simple epigenetic mechanism underlying the establishment and maintenance of immunological memory in T cells. By studying the transcriptional regulation of inducible genes we found that a single cycle of activation of… read more here.
Keywords: transcription; immunological memory; memory cells; chromatin priming ... See more keywords
Joining the PARty: PARP Regulation of KDM5A during DNA Repair (and Transcription?)
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200015
Abstract: The lysine demethylase KDM5A collaborates with PARP1 and the histone variant macroH2A1.2 to modulate chromatin to promote DNA repair. Indeed, KDM5A engages poly(ADP‐ribose) (PAR) chains at damage sites through a previously uncharacterized coiled‐coil domain, a… read more here.
Keywords: dna repair; dna; transcription; regulation ... See more keywords