Light-Induced Transcription Activation for Time-Lapse Microscopy Experiments in Living Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9674-2_17
Abstract: Gene expression can be monitored in living cells via the binding of fluorescently tagged proteins to RNA repeats engineered into a reporter transcript. This approach makes it possible to trace temporal changes of RNA production… read more here.
Keywords: microscopy; light induced; time; transcription activation ... See more keywords
A High-Throughput Screen for Transcription Activation Domains Reveals Their Sequence Features and Permits Prediction by Deep Learning.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.04.020
Abstract: Acidic transcription activation domains (ADs) are encoded by a wide range of seemingly unrelated amino acid sequences, making it difficult to recognize features that promote their dynamic behavior, "fuzzy" interactions, and target specificity. We screened… read more here.
Keywords: transcription; activation domains; transcription activation; acidic ads ... See more keywords
Transcription activation by the resistance protein AlbA as a tool to evaluate derivatives of the antibiotic albicidin
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d3sc00955f
Abstract: The rising numbers of fatal infections with resistant pathogens emphasizes the urgent need for new antibiotics. Ideally, new antibiotics should be able to evade or overcome existing resistance mechanisms. The peptide antibiotic albicidin is a… read more here.
Keywords: transcription; antibiotic albicidin; resistance; transcription activation ... See more keywords
Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac433
Abstract: Abstract Rob, which serves as a paradigm of the large AraC/XylS family transcription activators, regulates diverse subsets of genes involved in multidrug resistance and stress response. However, the underlying mechanism of how it engages bacterial… read more here.
Keywords: transcription; xyls family; transcription activation; rob ... See more keywords
Structural basis of three different transcription activation strategies adopted by a single regulator SoxS
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac898
Abstract: Abstract Transcription activation is established through extensive protein–protein and protein–DNA interactions that allow an activator to engage and remodel RNA polymerase. SoxS, a global transcription activator, diversely regulates subsets of stress response genes with different… read more here.
Keywords: transcription; transcription activation; structural basis; soxs ... See more keywords
Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky161
Abstract: Abstract Canonical bacterial transcription activators bind to non-transcribed promoter elements to increase transcription of their target genes. Here we report crystal structures of binary complexes comprising domains of Caulobacter crescentus GcrA, a noncanonical bacterial transcription… read more here.
Keywords: transcription; transcription activation; gcra; mechanism transcription ... See more keywords