A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2019.03.017
Abstract: Holoprosencephaly is the incomplete separation of the forebrain during embryogenesis. Both genetic and environmental etiologies have been determined for holoprosencephaly; however, a genetic etiology is not found in most cases. In this report, we present… read more here.
Keywords: subunit cnot1; transcription complex; cnot1; ccr4 transcription ... See more keywords
Architecture of a SARS-CoV-2 mini replication and transcription complex
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19770-1
Abstract: Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription complex (RTC) to play a pivotal role in the virus life cycle. Here we determine the atomic structure of a SARS-CoV-2 mini RTC, assembled by viral… read more here.
Keywords: replication transcription; sars cov; rna; transcription complex ... See more keywords
Ligustrazine alleviates pulmonary arterial hypertension in rats by promoting the formation of myocardin transcription complex in the nucleus of PSMCs.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13534
Abstract: PAH is a pathophysiological state of abnormally elevated pulmonary arterial pressure caused by drugs, inflammation, toxins, viruses, hypoxia and other risk factors. We studied the therapeutic effect and target of TMP (tetramethylpyrazine) in the treatment… read more here.
Keywords: promoting formation; transcription complex; pulmonary arterial; myocardin transcription ... See more keywords
Structural basis for transcription complex disruption by the Mfd translocase
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.62117
Abstract: Transcription-coupled repair (TCR) is a sub-pathway of nucleotide excision repair (NER) that preferentially removes lesions from the template-strand (t-strand) that stall RNA polymerase (RNAP) elongation complexes (ECs). Mfd mediates TCR in bacteria by removing the… read more here.
Keywords: basis transcription; mfd; complex disruption; transcription ... See more keywords